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BoKwon Son, Eung-Suk Kim, Seung-Young Yu; Long-term Outcome of Conventional and Half-fluence Photodynamic Theraphy for Chronic Central Serous Chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4675.
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To evaluate the long-term efficacy and safety of conventional photodynamic therapy (PDT) and half-fluence PDT in chronic central serous chorioretinopathy (CSC)
Retrospective review of chronic CSC patients treated with conventional PDT or half-fluence PDT and a minimum follow-up of 12 months between October 2007 and June 2015. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), neural retinal thickness (NRT), choroidal thickness (CT), recurrence of CSC after PDT and resolution of subretinal fluid (SRF) at 12, 24 and 36 months were assessed.
The study included 52 eyes completed the 36-month follow-up. 28 eyes received conventional PDT and 24 eyes received half-fluence PDT. The mean follow-up period was 45 months. The mean logMAR BCVA improved significantly (P < .001), both in the conventional group (from 0.36±0.32 to 0.15±0.27) and in the half-fluence group (from 0.31±0.29 to 0.15±0.28) at 36 months, without significant difference between the 2 groups (p=0.711). The mean CRT decreased significantly (P < .001), both in the conventional group (from 395.2±185 to 205.2±45.8) and in the half-fluence group (from 341.8±97.9 to 205.6±50.1), at 36 months, without significant difference between the 2 groups (p=0.362). Both groups showed significant reduction in CT at months 36 after PDT with significant difference (p<0.001). At 36 months, all patients in the both groups had complete absorption of subretinal fluid (SRF). There were no recurrence of SRF during the follow-up.
Both treatments were effective and safe in chronic central serous chorioretinopathy treatment with a significant improvement in the long term, both anatomic and visual, without recurrence of SRF.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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