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Agnes Yiu Jeung Choi, Lisa Nivison-Smith, Sieu Khuu, Barbara Zangerl, Nagi Assaad, Michael Kalloniatis; Translating visual field changes detected with stimuli within and outside complete spatial summation to optical coherence tomography findings in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4705.
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Previous work has shown that visual field (VF) test stimuli operating within complete spatial summation within the central VF reveal more functional loss in patients with ocular disease including age-related macular degeneration (AMD). We investigated whether differences in functional changes detected with different size stimuli translate to structural changes on spectral-domain optical coherence tomography (SD-OCT).
We measured VF thresholds of 1 eye from patients with intermediate AMD (n=7) and early AMD (n=1) (range: 56-80 years; mean: 70±8 years) using the Humphrey Visual Field Analyzer (HVFA) 10-2 full threshold paradigm with GI to GIII. Test locations with threshold values outside the 95% distribution compared to our normative database were flagged as VF events. SD-OCT imaging (Heidelberg Engineering) of the posterior pole was acquired for all 8 patients and each VF event mapped to a corresponding 287x287µm retinal area. Structural events were defined as an AMD-related abnormality of at least 50% being within the OCT window and summed up for each stimulus within each patient. VF events that corresponded to structural events were counted and expressed as a percentage of the total number of VF events known as the match rate.
Half of the patients scored higher (i.e. greater number of structural events) and 1 patient scored lower for stimuli within complete spatial summation than with GIII. Of these patients that scored higher, half also demonstrated a higher match rate (i.e. greater number of VF events that corresponded to structural events) for stimuli within complete spatial summation compared to GIII.
Visual field events detected by stimuli within complete spatial summation translated to AMD-related abnormalities on OCT more frequently than with GIII, which suggests that such stimuli may be more appropriate for the 10-2 paradigm in patients with intermediate AMD.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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