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RYOSUKE FUJINO, Tatsuya Inoue, Keiko Azuma, Hiroshi Murata, Ryo Asaoka, Ryo Obata; The correlation between visual function and morphologic changes in retinal vein occlusion. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4707. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To estimate the correlation between visual function and retinal morphologic changes in retinal vein occlusion (RVO)
17eyes of 17 patients with macular edema secondary to RVO were enrolled in the current study and were injected with anti-VEGF agents. Before and after the treatment, central retinal thickness (CRT) and macular volume of the central 2 mm circle (MV) were measured, using spectral-domain optical coherence tomography (SD-OCT) as retinal morphologic parameters. The best-corrected visual acuity (BCVA) and the mean retinal sensitivity of the 9 measured points in the central 4-degrees(MRS) were evaluated as visual functions. The MRS was measured with the microperimetry (MP-3,Nidek) . We investigated the correlation between visual functions and retinal morphologic parameters, using multivariate regression analyses.
Mean age of participants was72.35±6.13 years. All 17eyes of 17 patients gained the dry retinas after anti-VEGF treatments. The MRS showed a significant improvement from baseline after the treatment (baseline vs post; 19.56±5.18 vs 21.19±4.90 dB, p=0.032). However, mean BCVA did not show a significant improvement. (baseline vs post; 0.29±0.34 vs 0.21±0.25, p=0.14).Multivariate regression analysis showed that the preoperative MRS was adopted as an explanatory variable for preoperative BCVA (AICc=2.76). When the preoperative MV was selected as a response variable, the preoperative MRS was adopted as the explanatory variable (AICc=8.57). The changes of MRS were significantly correlated with those of MV (p=0.026). However, there was no significant correlation between MRS and CRT changes.
The present study showed that the retinal sensitivity may be effective as the parameter which is associated with retinal morphologic changes after the anti-VEGF treatment for RVO.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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