Abstract
Purpose :
To estimate the correlation between visual function and retinal morphologic changes in retinal vein occlusion (RVO)
Methods :
17eyes of 17 patients with macular edema secondary to RVO were enrolled in the current study and were injected with anti-VEGF agents. Before and after the treatment, central retinal thickness (CRT) and macular volume of the central 2 mm circle (MV) were measured, using spectral-domain optical coherence tomography (SD-OCT) as retinal morphologic parameters. The best-corrected visual acuity (BCVA) and the mean retinal sensitivity of the 9 measured points in the central 4-degrees(MRS) were evaluated as visual functions. The MRS was measured with the microperimetry (MP-3,Nidek) . We investigated the correlation between visual functions and retinal morphologic parameters, using multivariate regression analyses.
Results :
Mean age of participants was72.35±6.13 years. All 17eyes of 17 patients gained the dry retinas after anti-VEGF treatments. The MRS showed a significant improvement from baseline after the treatment (baseline vs post; 19.56±5.18 vs 21.19±4.90 dB, p=0.032). However, mean BCVA did not show a significant improvement. (baseline vs post; 0.29±0.34 vs 0.21±0.25, p=0.14).
Multivariate regression analysis showed that the preoperative MRS was adopted as an explanatory variable for preoperative BCVA (AICc=2.76). When the preoperative MV was selected as a response variable, the preoperative MRS was adopted as the explanatory variable (AICc=8.57). The changes of MRS were significantly correlated with those of MV (p=0.026). However, there was no significant correlation between MRS and CRT changes.
Conclusions :
The present study showed that the retinal sensitivity may be effective as the parameter which is associated with retinal morphologic changes after the anti-VEGF treatment for RVO.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.