June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Flash and Pattern ERG Findings in Schizophrenia and Their Relationships to Visual Function
Author Affiliations & Notes
  • Steven Silverstein
    Psychiatry, Rutgers University, Piscataway, New Jersey, United States
  • Docia Demmin
    Psychiatry, Rutgers University, Piscataway, New Jersey, United States
  • Roché Matthew
    Psychiatry, Rutgers University, Piscataway, New Jersey, United States
  • Quentin Davis
    LKC Technologies, Inc., Gaithersburg, Maryland, United States
  • Frank Taranto
    Diopsys, Inc., Pine Brook, New Jersey, United States
  • Aaina Menon
    Psychiatry, Rutgers University, Piscataway, New Jersey, United States
  • Footnotes
    Commercial Relationships   Steven Silverstein, None; Docia Demmin, None; Roché Matthew, None; Quentin Davis, LKC Technologies, Inc. (E); Frank Taranto, Diopsys, Inc. (E); Aaina Menon, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 4879. doi:
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    • Get Citation

      Steven Silverstein, Docia Demmin, Roché Matthew, Quentin Davis, Frank Taranto, Aaina Menon; Flash and Pattern ERG Findings in Schizophrenia and Their Relationships to Visual Function. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4879.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : In this ongoing study we are using flash and pattern electroretinography (fERG and pERG) to clarify the contributions of retinal signaling abnormalities to previously reported changes in contrast sensitivity, visual acuity, and contour integration in people with schizophrenia.

Methods : Data were collected on 24 patients and 25 age-matched healthy controls. fERG data were collected under both light- and dark-adapted conditions, using a range of flash intensities, backgrounds, and temporal frequencies. The primary fERG variables of interest were a-wave activity (reflecting photoreceptor response), b-wave activity (reflecting primarily bipolar cell activity) and the photopic negative response (PhNR) (reflecting ganglion cell activity). The primary pERG variables of interest were magnitude, magnitude D, and the magnitude D/magnitude ratio for low and high contrast stimuli.

Results : On photopic fERG tests, schizophrenia patients demonstrated significantly weaker photoreceptor response when a flash was presented against an unlit background (p<.05), and during a steady-state flicker test (p<.005). On scotopic tests, the rate of response gain per unit of intensity increase was significantly weaker for patients than controls (group x condition interaction p=.001). In both light- and dark-adapted conditions, patients demonstrated weaker signaling of bipolar cells (ps < .005). The schizophrenia group was also characterized by a weaker PhNR (p<.05). Multiple tests' a- and b- wave amplitudes were related to behavioral contrast sensitivity impairments in the schizophrenia group (ps < .05 or .001), but not to visual acuity or contour integration. The groups did not differ significantly on pERG variables. For patients only, significant relationships were observed between poorer contour integration and reduced pERG amplitudes and longer latencies (all ps either < .05 or .001). For controls only, higher pERG values were related to better near and far visual acuity (ps < .05 or .01).

Conclusions : These data suggest that both reduced signaling of photoreceptor and bipolar cells, as well as attenuated response gain, are associated with schizophrenia. Both rod and cone responses appear to be affected, and these changes may be related to the contrast sensitivity reduction in this group. The issue of ganglion cell function in schizophrenia is less clear, but its relationships to contour integration warrant further study.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.


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