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Yasuki Ito, Shoko Taira, Takeshi Iwase, Norie Nonobe, Shunsuke Yasuda, Hiroko Terasaki; Quantitative evaluation of diabetic retinopathy using optical coherence tomography angiography. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5025.
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© ARVO (1962-2015); The Authors (2016-present)
Optical coherence tomography (OCT) angiography is an emerging technique that delineates retinal vasculature non-invasively. Image processing software to analyze these images quantitatively was developed recently. The purpose of this study is to evaluate diabetic retinopathy (DR) using OCT angiography in a quantitative way.
Medical records of 222 eyes of 152 patients (average age: 58.8 ±11.4 years) were retrospectively reviewed. They were 22 normal eyes, 54 eyes of no DR (NDR), 33 eyes of mild nonproliferative DR (MDR), 51 eyes of moderate or severe nonproliferative DR (NPDR), and 62 eyes of proliferative retinopathy (PDR). Images of OCT angiography (Cirrus HD-OCT 5000 AngioPlex, 3x3 mm scans) were analyzed using a prototype software with 3 kinds of indices, i.e. vessel area density (AD), vessel skeleton density (SD) and vessel diameter index (VDI) were obtained. These parameters of the superficial and the deep layer were compared between the groups.
In the analysis of the superficial layer, average AD (%) of normal eyes, NDR, MDR, NPDR, and PDR were 41.5, 41.2, 40.7, 39.6, and 39.1, average SD (mm/mm2) were 22.4, 22.3, 21.4, 20.9, and 20.1, and average VDI were 1.86, 1.85, 1.90, 1.90, and 1.95, respectively. In the analysis of the deep layer, average AD of normal eyes, NDR, MDR, NPDR, and PDR were 33.3, 32.3, 31.4, 25.1, and 24.8, average SD were 17.4, 16.9, 16.4, 12.7, and 12.6, and average VDI were 1.92, 1.91, 1.93, 1.99, and 1.98, respectively. Both AD and SD of MDR, NPDR and PDR were significantly smaller than normal eyes in the superficial layer. Both AD and SD of NPDR and PDR were significantly smaller than normal eyes in the deep layer. VDI of NPDR and PDR were significantly larger than normal eyes in both superficial and deep layer.
Decrease of retinal capillary density and dilation of retinal capillaries could be detected using 3 kinds of parameters, which therefore may be useful to evaluate DR quantitatively.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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