Purchase this article with an account.
Keitaro Hase, Atsuhiro Kanda, Kousuke Noda, Susumu Ishida; A comprehensive analysis of serum levels of prorenin/renin and inflammation-associated molecules in proliferative diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5210.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Receptor-associated prorenin system (RAPS) plays a crucial role in ocular inflammation and neovascularization, also contributing to the development of proliferative diabetic retinopathy (PDR). In this study, we explored correlations between protein levels of RAPS components including prorenin/renin and inflammation-associated molecules in the serum obtained from patients with PDR.
Serum samples were obtained from 40 consecutive patients, including 20 cases with non-angiogenic ocular diseases with idiopathic macular diseases including epiretinal membrane (ERM) and idiopathic macular hole (MH) (aged 63.4±4.3 y/o), and 20 cases with PDR (aged 62.4±8.7 y/o). Protein levels of prorenin/renin and inflammation-associated molecules, including tumor necrosis factor (TNF)-α, vascular adhesion protein-1 (VAP)-1, C-C chemokine ligand (CCL)2/monocyte chemotactic protein (MCP)-1, and interleukin (IL)-6 were determined by using a commercially available multiplex bead analysis system and enzyme-linked immunosorbent assay.
As compared to control serum, protein levels of prorenin/renin, IL-1β, VAP-1, FactorD/Adipsin, and TNF-α, but not CCL2/MCP-1 or IL-6, significantly increased in PDR serum. Serum prorenin/renin correlated positively with IL-1β, FactorD/Adipsin and TNF-α in patients with PDR, but not in those with ERM and MH.
The current data demonstrate the elevated serum levels of prorenin/renin and correlations among prorenin/renin, IL-1β, FactorD/Adipsin and TNF-α in patients with PDR, suggesting a potential role of the RAPS in the pathogenesis of PDR.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
This PDF is available to Subscribers Only