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Eung-Suk Kim, Kiyoung Kim, Hong Hyun Sook, Seung-Young Yu; The inhibitory effect of substance P on retinal neurodegeneration with diabetic rat model. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5221.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate inhibition effect of retinal neurodegeneration change in Type 2 diabetic rats (OLETF) after intravenous Substance P (SP) injection
Retinal nerve fiber layer (RNFL) thicknesses were measured manually at 1300 μm from the center of the optic nerve head using SD-OCT. 5nmole/kg Substance P was injected intravenously twice a week from 27 to 30 weeks. Histologic and immunologic cell staining, serum inflammatory cytokines, and bone marrow colony forming efficiency were measured at 31 week
At 28 weeks, RNFL thickness was significantly lower in OLETF than control group. From 29 weeks (2 weeks after injection) RNFL thickness showed significant increase in SP injection group maintained by 31 weeks. In histologic analysis, SP injection group presented decrease of GFAP staining, cell apoptosis, and serum inflammatory cytokines. Whereas, infiltration of inflammatory cells and bone marrow colony forming efficiency were higher than control group
Substance P injection showed inhibitory effect in retinal neurodegeneration as early change of diabetic retinopathy via anti-inflammatory effect and enhancements of mesenchymal stem cells-mediated immune modulation
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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