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Sung Pyo Park, Seonghwan shin; Relationship between aqueous humor 25-hydroxyvitamin D and age related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5232.
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Inflammation had been found to play an underlying role in age related macular degeneration (AMD). Vitamin D, a circulating steroid hormone, has properties that counteract inflammation. We aimed to determine the association between the aqueous humor 25-hydroxyvitamin D and age related macular degeneration.
We selected the AMD patients who were subdivided into the two groups based on pigmented epithelial detachment (PED) type (serous and mixed PED; group1, fibrovascular PED; group2). The both groups were injected with ranibizumab or aflibercept in vitreous cavity and aqueous humor were sampled by anterior chamber paracentesis. The humor 25-hydroxyvitamin D was analyzed by colorimetric and competitive assay with ELISA kit.
The humor 25-hydroxyvitamin D level in AMD patients was significantly lower as compared to controls (10.03ng/mL vs 40.8ng/mL; p < 0.001). And the humor 25-hydroxyvitamin D level in group 1 was lower as compared to that in group 2 (6.38ng/mL vs 14.65ng/mL; P = 0.002). The macrophage induced protein-1α (MIP-1α) seemed to be similar with humor vitiamin D level.
This is the first study which analyzes the humor 25-hydroxyvitamin D level in AMD patients. The results were inversely associated with wet AMD which was compared of the patients without any macular degeneration. These associations suggest that further research is necessary regarding vitamin D deficiency as a potentially modifiable risk factor for the development of AMD.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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