Abstract
Purpose :
To determine the correlation of structural and functional changes visualized using high-resolution optical coherence tomography (OCT) with microperimetric retinal sensitivity in high myopia.
Methods :
Cross-sectional study. Thirty-one eyes of 31 patients with high myopia were age-matched with Thirty-one normal eyes of 31 subjects. All subjects underwent OCT and MP1 microperimeter measurements to obtain the parameters of retinal perfusion, macular structure, and retinal sensitivity. Pearson correlation analysis was performed to analyze the relationship among retinal perfusion, macular structure, and retinal sensitivity in high myopia.
Results :
The parameters obtained from OCT angiography indicated that retinal perfusion were reduced in high myopic eyes compared to controls. The total thickness of outer retinal layer and retinal pigment epithelium layer (ORLRPE), as well as choroidal thickness, were thinner than those in controls. The retinal sensitivity were reduced in high myopia eyes compared to controls (P < 0.001). Retinal sensitivity loss was correlated with both choroidal thinning (r=0.416, P=0.020) and structural loss of ORLRPE (r=0.405, P=0.024). There was no correlation or paradoxical correlation between retinal perfusion and retinal sensitivity (P> 0.05).
Conclusions :
It appears that there is a close link among choroidal thinning, structural loss of ORLRPE and retinal sensitivity defect in high myopia. We hypothesize that reduced retinal perfusion from the choroidal in high myopia may occur before the structural and functional changes of the retina. A follow-up cohort study of high myopic subjects is planned to address the hypothesis.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.