Abstract
Purpose :
To examine the relationships between baseline structural parameters and functional progression in open angle glaucoma (OAG) patients after 5 years.
Methods :
111 OAG patients (mean age 65 yrs; 44 male) were assessed at baseline for optic nerve head morphology by Heidelberg retinal tomography 3 (HRT3). Functional progression was evaluated every 6 months for 5 years by 24-2 Swedish interactive threshold algorithm visual field (VF) (Humphrey). Progression was defined as 2 consecutive visits with mean deviation decrease by at least 2 compared to baseline and/or advanced glaucoma intervention study (AGIS) increase by at least 2 compared to baseline. Mixed-model ANCOVA was used to test for statistically significance changes from baseline to 5-year follow-up. Time to functional progression was analyzed using Cox proportional hazards survival analysis.
Results :
Statistically significant shorter time to functional progression was associated with higher baseline cup area 0.870 (95% CI=0.735, 1.015), cup/disc area ratio 0.410 (0.359, 0.461), linear cup/disc ratio 0.619 (0.573, 0.665), cup shape -0.128 (-0.149, -0.108), and lower baseline rim area 1.268 (1.159, 1.377), rim volume 0.295 (0.246, 0.344), height variation contour 0.330 (0.297, 0.366), mean RNFL thickness 0.196 (0.172, 0.219), and RNFL cross-sectional area 1.025 (0.901, 1.148) (all p<0.05).
Conclusions :
In OAG patients, baseline optic nerve head and retinal structural parameters were predictive of shorter time to functional progression after 5 years.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.