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Cheolmin Yun, Jaeryung Oh, Seong-Woo Kim, Jun Ho Yoo; Ocular perfusion pressure and choroidal thickness in central serous chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5922.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the ocular perfusion pressure (OPP) and choroidal thickness (CT) in patients with central serous chorioretinopathy (CSC).
In this retrospective study, consecutive patients with CSC were classified into two groups with pigment epitheliopathy (PE group) or without PE (non-PE group) in their fellow eyes. PE was defined as any of the following, semicircular or irregular flat pigment epithelial detachment (PED) or retinal pigment epithelial protrusion, is visible on the 6 x 6 mm zone of macular on optical coherence tomography. We compared systemic and ocular factors among patients groups and age-matched normal controls. The mean OPP was obtained from BP and intraocular pressure (IOP). OPP was calculated from mean arterial pressure (MAP) and IOP using the following formula, Mean OPP = 2/3 x MAP – IOP. The MAP was obtained from systolic blood pressure (SBP) and diastolic blood pressure (DBP) with a following formula, MAP = DBP + 1/3(SBP – DBP). CT was measured at the center of fovea, 500 μm, 1000 μm and 1500 μm from nasally and temporally and the mean of these values were defined as mean macular CT.
We included 94 eyes of 47 CSC patients and 47 eyes from normal controls. Of 47 patients, 21 (44.7%) patients were classified into PE group and 26 (55.3%) into non-PE group. Age and sex were not different among patient groups and normal controls. However, PE group had higher prevalence of prehypertension than non-PE group or normal control group (P = 0.043). Mean OPP of CSC and fellow eyes in group PE (50.02 ± 4.98 and 50.83 ± 4.12 mmHg) were greater than that of non-PE group (43.69 ± 6.88 and 44.0 ± 6.57 mmHg) and normal controls (45.64 ± 8.73 and 45.64 ± 8.73 mmHg) (all, P < 0.05). Mean macular CT of CSC and fellow eyes in PE group was thicker than that of non-PE group (P= 0.028 and P = 0.014). In multivariate analysis, greater macular CT and higher OPP were associated with the PE on fellow eyes (P = 0.002, OR = 1.043 and P = 0.003, OR = 1.315, respectively).
Thicker choroid and higher OPP were associated with the PE on fellow eyes of CSC patients. Increased OPP might contribute the bilateral characteristics of CSC.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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