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Akiko Miki, shigeru honda, Yoichi Sakurada, kohji tanaka, Yoshinori Mitamura, Makoto Nakamura; Association between CFH variants and choroidal thickness in central serous chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5925. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
We previously reported the association between central serous chorioretinopathy (CSC) and complement factor H (CFH) gene variants. In this study, we analyze the association between the choroidal thickness (CCT) in eyes with CSC and CFH gene variants.
Patients were recruited from four collaborating hospitals in Japan including Kobe university hospital. One hundred and seventy two eyes of 172 patients (men 77.9%) were enrolled. The average age (mean±SD) was 53.8±11.1years. We manually measured CCT on SD-OCT taken by enhanced depth imaging technique. Genotyping of five single nucleotide polymorphisms (SNPs) including CFH I62V (rs800292), CFH (rs3753394, rs2284664, rs1329428, rs1065489), which we previously reported, were conducted using Taqman technology.
The average CCT (mean±SD ) in patients with CC genotype of rs2284664(C/T) was 425.1±139.9mm, 388.4±140.8 mm in patients with CT+TT genotype. There was a significant difference between 2 groups (p=0.043). There was no significant difference in the CCT among genotypes of other 4 snps.
It is suggested that rs2284664 in CFH region may effect the CCT in patients with CSC.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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