June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Topographic correlation of retinal pigment epithelial detachment to choroidal filling defects in central serous chorioretinopathy
Author Affiliations & Notes
  • Juan Lyn Ang
    Canberra Hospital, Canberra, Australian Capital Territory, Australia
  • Jocelyne Rivero Alvarez
    Canberra Hospital, Canberra, Australian Capital Territory, Australia
  • Chandra Bala
    Royal Perth Hospital, Perth, Western Australia, Australia
  • Kanishka Randev Mendis
    Canberra Hospital, Canberra, Australian Capital Territory, Australia
  • Footnotes
    Commercial Relationships   Juan Lyn Ang, None; Jocelyne Rivero Alvarez, None; Chandra Bala, None; Kanishka Mendis, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 5927. doi:
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    • Get Citation

      Juan Lyn Ang, Jocelyne Rivero Alvarez, Chandra Bala, Kanishka Randev Mendis; Topographic correlation of retinal pigment epithelial detachment to choroidal filling defects in central serous chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5927.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : Choroidal filling defects (CFD) and retinal pigment epithelial detachments (PED) have been reported to be associated with central serous chorioretinopathy (CSC).
The localized shut down of the choriocapillaris (CC) could lead to an alteration in the trans-retinal pigment epithelium (RPE) hydrostatic pressure differential, affect the hydraulic conductivity, and lead to a delamination of the RPE from the Bruch’s membrane causing a PED.
There is paucity, in the literature correlating the topography of the PED with CFD.

Methods : This was a retrospective study. All consecutive patients diagnosed with CSC using optical coherence tomography (OCT) and fluorescein angiography (FA) at the retinal service at Canberra Hospital, Australia between 2012-2016 were included. Patients with poor quality images and those with exudative maculopathy due to choroidal neovascularisation secondary to CSC were excluded.
CSC diagnosis was confirmed in all selected patients with classic OCT features and typical ‘smoke stack’, ‘inkblot’ leak pattern on FA. Patients without the typical FA leak pattern were excluded.
CFD was defined as patchy choroidal hypofluorescence that remained hypofluorescent into the late venous phase of the FA. PED was defined as a smooth elevation of the RPE as seen on spectral domain OCT.
Topographic relationships between PED location and CFD, as seen on FA, were subsequently determined.
The outcome measure was the anatomical correlation of the CFD to PED.

Results : A total of 40 patients were identified and 39 eyes of 36 patients were selected for further investigation. Then mean age was 43.6 years (±9.4 years). There were 32 males and 4 females. Five patients reported a history of steroid use and 10 patients reported stressful life events related to presentation.
There were 9 eyes with a smoke stack and 30 eyes with an inkblot RPE leak pattern on FA. There were 32 eyes (82.1%) with a CFD and 13 eyes (33.3%) with a PED. The eyes with PED correlated 100% with CFD.

Conclusions : The degree of topographic correlation of PED to CFD may imply a causative relationship however this result will require further investigation and reproduction.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.


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