July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Reducing Adenoviral Patient Infected Days (RAPID): Prevalence of Polymerase Chain Reaction (PCR) Confirmed Adenovirus Among Patients Presenting With Acute Conjunctivitis
Author Affiliations & Notes
  • Mary Migneco
    Ophthalmology, Washington University in St. Louis, St. Louis, Missouri, United States
  • Mathew Margolis
    Ophthalmology, Washington University in St. Louis, St. Louis, Missouri, United States
  • Christina Morettin
    Illinois College of Optometry, Chicago, Illinois, United States
  • Tammy Than
    Carl Vinson VAMC, Dublin, Georgia, United States
  • Meredith Whiteside
    University of California-Berkeley, Berkeley, California, United States
  • Ellen Shorter
    Illinois Eye and Ear Infirmary, Chicago, Illinois, United States
  • Jennifer S Harthan
    Illinois College of Optometry, Chicago, Illinois, United States
  • Spencer Johnson
    Northeastern State University, Tallequah, Oklahoma, United States
  • Andy Hartwick
    Ohio State University, Columbus, Ohio, United States
  • Kelly Olsen
    Brooke Army Medical Center, Fort Sam Houston, Texas, United States
  • Tave van Zyl
    Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Julia Huecker
    Ophthalmology, Washington University in St. Louis, St. Louis, Missouri, United States
  • Crystal Rosemann
    Brooke Army Medical Center, Fort Sam Houston, Texas, United States
  • Mae O. Gordon
    Ophthalmology, Washington University in St. Louis, St. Louis, Missouri, United States
  • Footnotes
    Commercial Relationships   Mary Migneco, None; Mathew Margolis, None; Christina Morettin, None; Tammy Than, None; Meredith Whiteside, None; Ellen Shorter, None; Jennifer Harthan, None; Spencer Johnson, None; Andy Hartwick, None; Kelly Olsen, None; Tave van Zyl, None; Julia Huecker, None; Crystal Rosemann, None; Mae Gordon, None
  • Footnotes
    Support  NEI Grant 1R34EY023633-01A1 and NEI Grant P30EY002687
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 115. doi:
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      Mary Migneco, Mathew Margolis, Christina Morettin, Tammy Than, Meredith Whiteside, Ellen Shorter, Jennifer S Harthan, Spencer Johnson, Andy Hartwick, Kelly Olsen, Tave van Zyl, Julia Huecker, Crystal Rosemann, Mae O. Gordon; Reducing Adenoviral Patient Infected Days (RAPID): Prevalence of Polymerase Chain Reaction (PCR) Confirmed Adenovirus Among Patients Presenting With Acute Conjunctivitis. Invest. Ophthalmol. Vis. Sci. 2018;59(9):115.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare the reported prevalence of adenovirus among patients presenting with acute conjunctivitis in our national, multi-center study to four published reports. We examine the effect of season and geographic region on the estimate of the prevalence of PCR confirmed adenovirus.

Methods : From October 2015 to April 2017, eight medical centers in seven geographically diverse regions in the United States screened patients presenting with clinical signs of acute conjunctivitis for eligibility in a pilot clinical trial of an investigational treatment of adenoviral conjunctivitis. Patients ≥18 years of age and those with symptom onset ≤4 days prior to presentation were screened. All patients screened were included in prevalence analysis regardless of randomization status into the RAPID study. Tear samples were collected from the first affected eye and evaluated by PCR. We report overall prevalence of PCR confirmed adenovirus, seasonal variation, and geographic regions.

Results : A total of 104 patients who presented with acute conjunctivitis were screened. The overall prevalence of PCR confirmed adenovirus in tear samples was 15% (16/104). Prevalence of adenovirus was 37% during the spring, 8% during the summer, 10% during the fall, and 12% during the winter. Prevalence varied markedly by region from 0% (0/12) to 36% (5/11). In four published reports of patients presenting with acute conjunctivitis, the prevalence of PCR confirmed adenovirus was 8% (44/542 over 36 months; Baltimore), 25% (47/186 over 8 months, prevalence not reported by region), 27% (34/125; season/duration and prevalence not reported by region), 62% (31/52 in July-October; Philadelphia).

Conclusions : The prevalence of PCR confirmed adenovirus in patients presenting with acute conjunctiviitis in our study was lower than most published reports. The prevalence of PCR confirmed adenovirus varied considerably by season and geographic region. Studies conducted in different seasons and geographic regions report similar variations in prevalence.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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