July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
The Association Between Pterygium and Elevated Serum Alkaline Phosphatase Level in the South Korean Population: A National Wide Cross-Sectional Study
Author Affiliations & Notes
  • Soo Han Kim
    Department of Ophthalmology, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do, Korea (the Republic of)
  • Hee Kim
    Department of Occupational Therapy, Konyang University, Daejeon, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Soo Han Kim, None; Hee Kim, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 126. doi:
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      Soo Han Kim, Hee Kim; The Association Between Pterygium and Elevated Serum Alkaline Phosphatase Level in the South Korean Population: A National Wide Cross-Sectional Study. Invest. Ophthalmol. Vis. Sci. 2018;59(9):126.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : In this study we investigated whether elevated serum Alkaline phosphatase (ALP) is related to prevalence, location, type, recurrence of pterygium and also length in the South Korean population.

Methods : A national wide cross-sectional study data Korean National Health and Nutrition Examination Survey form 2008-2011 was used in this study. Participants over 30 years old, performed both ALP test and ophthalmic evaluation were included (N = 22359). One-way analysis of variance, chi-square test, and Fisher’s exact test were used to compare characteristics and outcomes of the participants. Multivariable logistic regression was used to examine the association between serum ALP level and various type of pterygium. Known risk factors for development of pterygium and ALP elevation were adjusted (age, sex, residence, sunlight exposure, drinking, smoking, hypertension, diabetes, BMI, AST, ALT, Vitamin D and HDL)

Results : The overall prevalence of pterygium was 8.1% and subjects with pterygium had higher level of serum ALP (P <0.001). Subjects with higher serum ALP had significant higher prevalence of all types of pterygium than those of lower serum ALP quartiles. After adjusting potential confounding factors, multivariate logistic regression analysis showed that ALP was associated with the prevalence of pterygium(OR:1.001, p-value: 0.038) . Trend analysis between odds ratio and ALP quartiles showed linear trend in overall prevalence and in intermediate type of pterygium. Subgroup analysis stronger correlation in participants aged over 50. One way ANOVA showed association between size of pterygium and serum ALP quartile levels. Serum ALP did not show association with recurrence of pterygium.

Conclusions : Increased serum ALP was related to prevalence and size of pterygium.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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