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jaeyeun lee, JoonMo Kim, Ki Ho Park; The effect of the history of delivery on the development of open-angle glaucoma.. Invest. Ophthalmol. Vis. Sci. 2018;59(9):176.
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To investigate the association between factors associated with delieveries and open-angle glaucoma (OAG) in Korean females.
A population-based, cross-sectional survey was performed using a multistage, stratified, probability-clustered sampling method from the Korean National Health and Nutrition Examination Survey (KNHANES) between 2010 and 2011. Postmenopausal female participants (n=1,790) enrolled. We obtained information on demographics, comorbidities, and health-related behaviors via interview with a standardized protocol from every participant and performed comprehensive ophthalmic examinations. Glaucoma diagnosis was based on criteria established by the International Society of Geographic and Epidemiologic Ophthalmology. Multivariate regression analysis was used to assess the correlation between gravida and deliveries and the prevalence of OAG in all enrolled subjects.
The prevalence of OAG was 6.29% in women. Subjects with OAG had significantly higher numbers of deliveries and vaginal deliveries and younger age at first delivery. Subjects who had four deliveries showed a high risk of OAG compared with subjects with two deliveries (multivariate logistic regression analysis, OR=3.10; 95% CI: 1.38–6.94, p=0.006). Age at first delivery of 16-20 years and 21–23 years showed about 2-fold increased risk for OAG compared with the reference group(24-26years) (aOR; 2.04 (95% CI 1.02–4.07, p=0.044, aOR; 2.00 (95% CI 1.11–3.62, p=0.022, respectively).
History of single gravida, four deliveries, and first delivery at age younger than 24 years were associated with an increased risk for OAG. These results suggest that changes or events during the period from pregnancy to delivery affect the development of glaucoma.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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