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Jee Taek Kim, Min-Gyu Choi; Systemic factors associated with choroidal thickness in eyes with diabetic retinopathy.. Invest. Ophthalmol. Vis. Sci. 2018;59(9):197. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate systemic factors that affect choroidal thickness (ChT) in eyes with diabetic retinopathy (DR), using swept-source optical coherence tomography (SS-OCT).
Retrospective chart review was performed between Mar. 2015 and Feb. 2017 in patients who had visited department of ophthalmology and endocrinology at Chung-Ang university hospital. All patients underwent complete ophthalmologic examination, SS-OCT imaging, and comprehensive laboratory evaluations including complete blood cell count, blood chemistry, urinalysis. Systemic factors that associated with the change of ChT in eyes with DR, were analyzed. Pearson correlation analysis, univariate linear analysis, and multivariate linear analysis were used to analyze.
Total of 156 diabetic eyes - 16 with no diabetic retinopathy (DR), 23 with mild to moderate nonproliferative DR (mNPDR), 49 with severe NPDR (sNPDR), 57 with naive proliferative DR (PDR) and 11 with treated PDR, and 20 age-matched nondiabetic control eyes.Mean age of patients was 54.26±10.34 years old. Mean duration of diabetes was 16.99±26.62 years. Mean retinal thickness in eyes with no DR, mNPDR, sNPDR, naïve PDR, and treated PDR were 231.47±48.51um, 224.77±48.64 um, 225.44±70.88 um, 247.82±106.70 um and 311.50±61.34 um, respectively.Mean choroidal thickness in eyes with no DR, mNPDR, sNPDR, naïve PDR, and treated PDR were 216.60±48.51 um, 259.45±73.45 um, 280.00±88.42 um, 306.04±64.38 um and 296.10±57.88 um, respectively.Univariate and multivariate analysis reveal that DR severity, DME existance, and intake of PPAR had positive effect on ChT, and age, disease duration, axial length, microalbuminuria, and nephropathy had negative effect of ChT.
Several systemic factors were associated with ChT.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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