July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Association between Macular Blood Flow and Choroidal Structure and their Relationships to Visual Function in Retinitis Pigmentosa
Author Affiliations & Notes
  • Yusuke Murakami
    Department of Ophthalmology, Kyushu University, Fukuoka, FUKUOKA, Japan
  • Jun Funatsu
    Department of Ophthalmology, Kyushu University, Fukuoka, FUKUOKA, Japan
  • Shunji Nakatake
    Department of Ophthalmology, Kyushu University, Fukuoka, FUKUOKA, Japan
  • Kohta Fujiwara
    Department of Ophthalmology, Kyushu University, Fukuoka, FUKUOKA, Japan
  • Takashi Tachibana
    Department of Ophthalmology, Kyushu University, Fukuoka, FUKUOKA, Japan
  • Toshio Hisatomi
    Department of Ophthalmology, Kyushu University, Fukuoka, FUKUOKA, Japan
  • Shigeo Yoshida
    Department of Ophthalmology, Kyushu University, Fukuoka, FUKUOKA, Japan
  • Shozo Sonoda
    Ophthalmology, Kagoshima University, Kagoshima, Japan
  • Taiji Sakamoto
    Ophthalmology, Kagoshima University, Kagoshima, Japan
  • Koh-hei Sonoda
    Department of Ophthalmology, Kyushu University, Fukuoka, FUKUOKA, Japan
  • Yasuhiro Ikeda
    Department of Ophthalmology, Kyushu University, Fukuoka, FUKUOKA, Japan
  • Footnotes
    Commercial Relationships   Yusuke Murakami, None; Jun Funatsu, None; Shunji Nakatake, None; Kohta Fujiwara, None; Takashi Tachibana, None; Toshio Hisatomi, None; Shigeo Yoshida, None; Shozo Sonoda, None; Taiji Sakamoto, None; Koh-hei Sonoda, None; Yasuhiro Ikeda, None
  • Footnotes
    Support  the Japanese Ministry of Education, Culture, Sports, Science, and Technology grants #16H06268; a Japanese Retinitis Pigmentosa Society grant, and a Rohto Award
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 21. doi:
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    • Get Citation

      Yusuke Murakami, Jun Funatsu, Shunji Nakatake, Kohta Fujiwara, Takashi Tachibana, Toshio Hisatomi, Shigeo Yoshida, Shozo Sonoda, Taiji Sakamoto, Koh-hei Sonoda, Yasuhiro Ikeda; Association between Macular Blood Flow and Choroidal Structure and their Relationships to Visual Function in Retinitis Pigmentosa. Invest. Ophthalmol. Vis. Sci. 2018;59(9):21.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the relationships between macular blood flow as measured by laser speckle flowgraphy (LSFG), the choroidal structure in the enhanced depth imaging optical coherence tomography (EDI-OCT), and central visual function in patients with retinitis pigmentosa (RP).

Methods : We studied 52 consecutive typical RP patients ≤50 years old and 21 age- and gender-matched controls. The mean blur rate (MBR), that represents blood flow volume, was calculated in a 2.4 x 2.4 mm area centered on the fovea by LSFG. Subfoveal horizontal EDI-OCT images were recorded, and the choroidal area, choroidal hypo-reflective area, and choroidal hyper-reflective area were analyzed in the central 2.4 mm width region. Visual acuity (VA), mean deviation (MD) and averaged macular sensitivity of static perimetry tests (Humphrey Filed Analyzer, the central 10-2 program) were measured in RP patients.

Results : MBR, choroidal area, choroidal hypo-reflective area, and choroidal hyper-reflective area were significantly decreased in RP patients (all P < 0.001, vs. controls). Spearman’s rank testing demonstrated no significant correlation between MBR and the choroidal structural parameters in RP patients. Decreased MBR was associated with reduction in VA, MD, and macular sensitivity (all P < 0.05), while the choroidal structural parameters did not correlate with central visual function.

Conclusions : These results demonstrated the divergence between the choroidal structure and blood function, and suggest that decreased blood flow, rather than the alteration of choroidal structure, was better associated with central visual function in RP patients.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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