July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Relationships among Spectral Domain Optical Coherence Tomography (SD-OCT) Parameters and Semi-automated Kinetic Perimetry (SKP) Parameters in Subjects with Autosomal Dominant Retinitis Pigmentosa (adRP)
Author Affiliations & Notes
  • Kirsten G Locke
    Retina Foundation of the Southwest, Dallas, Texas, United States
  • Donald C Hood
    Visual Science Laboratory, Department of Psychology and Ophthalmology, Columbia University, New York, New York, United States
  • David G Birch
    Retina Foundation of the Southwest, Dallas, Texas, United States
    Department of Ophthalmology, UT Southwestern Medical Center, Dallas, Texas, United States
  • Footnotes
    Commercial Relationships   Kirsten Locke, None; Donald Hood, Heidelberg Engineering (C), Heidelberg Engineering (F), Heidelberg Engineering (R), Topcon Inc (R), Topcon Inc (C), Topcon Inc (F); David Birch, None
  • Footnotes
    Support  NH Grant EY09076
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 28. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Kirsten G Locke, Donald C Hood, David G Birch; Relationships among Spectral Domain Optical Coherence Tomography (SD-OCT) Parameters and Semi-automated Kinetic Perimetry (SKP) Parameters in Subjects with Autosomal Dominant Retinitis Pigmentosa (adRP). Invest. Ophthalmol. Vis. Sci. 2018;59(9):28.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Because SD-OCT and SKP are potential sources of outcome measures for clinical trials in inherited retinal disease (IRD), we investigated the relationships among the structural and functional parameters derived from these measures.

Methods : Vertical SD-OCT line scans and SKP were performed on or close to the same day for patients with adRP (n=20, age: 17-71 yrs) with various degrees of progression. Only eyes where both endpoints of the ellipsoid zone (EZ), external limiting membrane (ELM), and outer nuclear layer (ONL) could be identified on SD-OCT were included. Each scan was captured at an ART (Automatic Real-time Tracking) of 100, using the Spectralis (Heidelberg Engineering, USA), while centered on the fovea. The endpoints of EZ and ELM were identified on both sides of the fovea. The endpoints of the ONL were taken where the band had become a thin unchanging line. The isopters for V4e, III4e and I4e test targets were obtained with SKP (Octopus 900, Haag-Streit), using an angular velocity of 4°/sec. Blind spots were tested at angular velocity of 2°/sec. Isopter diameters were measured in degrees along the vertical meridian.

Results : Stepwise multiple regression with the 3 spot sizes as the dependent variables revealed that the only significant relationship was between OCT ONL diameter and SKP I4e diameter (p=0.0049). Based upon Bland-Altman plots, the average difference between the I4e field and ONL diameters was 1.1° (95% CI: -5.1° – 2.9°). Average ELM diameter was 5° less and EZ diameter was 6.7° less than the average I4e field diameter. The diameter of III4e was 24.7°, 28.6° and 30.2° larger than ONL, ELM and EZ diameters, respectively. For spot size V, the disparities were 41.7°, 45.7°, and 47.3°.

Conclusions : The field diameter for spot size I4e is closely related to the diameter of the ONL. Thus, the I4e field diameter can be used to select subjects with measurable EZ and ONL regions within an OCT scan area. Perhaps surprisingly, even the smallest kinetic target with a diameter of 0.11° is detected outside of the EZ, suggesting that considerable vision is possible with minimal photoreceptor structure visible on SD-OCT images. This apparent mismatch between structure and function becomes even more evident with larger test targets.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×