July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Relationship between intraocular pressure reduction and visual field aggravation after trabeculectomy in eyes with open angle glaucoma
Author Affiliations & Notes
  • SHUNSUKE TAKAHASHI
    Gifu University Graduate School of Medicine, Gifu, Japan
  • Akira Sawada
    Gifu University Graduate School of Medicine, Gifu, Japan
  • Tetsuya Yamamoto
    Gifu University Graduate School of Medicine, Gifu, Japan
  • Footnotes
    Commercial Relationships   SHUNSUKE TAKAHASHI, None; Akira Sawada, None; Tetsuya Yamamoto, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 460. doi:
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      SHUNSUKE TAKAHASHI, Akira Sawada, Tetsuya Yamamoto; Relationship between intraocular pressure reduction and visual field aggravation after trabeculectomy in eyes with open angle glaucoma. Invest. Ophthalmol. Vis. Sci. 2018;59(9):460.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To explore relationship between intraocular pressure (IOP) reduction and visual field aggravation after trabeculectomy with intraoperative use of mitomycin C (MMC).

Methods : We retrospectively investigated 1286 eyes of 1948 patients with primary open angle glaucoma including normal tension glaucoma and exfoliation glaucoma, who received trabeculectomy with MMC. Inclusion criteria are follows: postoperative follow-up periods ≥ 10 years, preoperative mean deviation (MD) > -20 decibels (Humphrey Field Analyzer program Central 30-2), and reliable postoperative visual field results ≥ 10 times. We reviewed the patients’ data including IOP and visual field from our records. A regression analysis was conducted to assess a relationship between percent reduction of IOP form baseline value and MD slope.

Results : Finally 128 eyes met the inclusion criteria. The mean age at surgical intervention was 49.9 ± 13.1 years. Men were 70, and women were 58. The mean follow-up period was 17.8 ± 4.9 years. The preoperative IOP was 19.2 ± 5.1 mmHg. The postoperative IOP reduced significantly to 11.1 ± 3.2 mmHg (P < 0.001; paired t-test), and percent IOP reduction from baseline was 40.0 ± 18.5 %. The eyes with a percent IOP reduction below 20 and 30% were 18 and 38 eyes, respectively. The postoperative MD slope was -0.12 ± 0.34 decibel/year, which was significantly correlated with the percent IOP reduction from baseline (r = 0.341, P < 0.001; Pearson correlation coefficient).

Conclusions : Long-term IOP stability obtained by trabeculectomy can preserve the visual field in glaucoma.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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