July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Comparison of changes in mGCIPL thickness between medically and surgically treated eyes with advanced glaucoma
Author Affiliations & Notes
  • Masahiro Onda
    Gifu Graduate School of Medicine , Gifu, Japan
  • Akira Sawada
    Gifu Graduate School of Medicine , Gifu, Japan
  • Hiroko Inuzuka
    Gifu Graduate School of Medicine , Gifu, Japan
  • Tetsuya Yamamoto
    Gifu Graduate School of Medicine , Gifu, Japan
  • Footnotes
    Commercial Relationships   Masahiro Onda, None; Akira Sawada, None; Hiroko Inuzuka, None; Tetsuya Yamamoto, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 462. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Masahiro Onda, Akira Sawada, Hiroko Inuzuka, Tetsuya Yamamoto; Comparison of changes in mGCIPL thickness between medically and surgically treated eyes with advanced glaucoma. Invest. Ophthalmol. Vis. Sci. 2018;59(9):462.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To compare changes in the macular ganglion cell layer and inner plexiform layer (mGCIPL) thickness over 5 years between surgically treated eyes (STE) and medically treated eyes (MTE) with advanced glaucoma.

Methods : We retrospectively investigated 86 patients comprising 43 with advanced open angle glaucoma (OAG) with trabeculectomy and 43 with medically treated OAG. The mGCIPL thickness was measured more than 5 times during follow-up by optical coherence tomography.

Results : The mean age at study initiation was 62.5 ± 9.2 years in STE and 62.7 ± 9.5 years in MTE. The averaged mean deviation (MD) according to the Humphrey Field Analyzer central program 30-2 was -18.65 ± 4.76 dB in STE and -18.38 ± 4.19 dB in MTE at the first observation (P = 0.983; Mann-Whitney U test). The mGCIPL thickness in each sector showed no significant differences at initial measurement. The averaged intraocular pressure (IOP) throughout follow-up was 10.5 ± 2.0 mmHg in STE and 10.8 ± 0.8 mmHg in MTE (P = 0.429; Mann-Whitney U test). There was no significant difference in the MD changes over 5 years between the two groups (P = 0.405; Mann-Whitney U test). Changes in the mGCIPL thickness over 5 years in MTE were significantly greater than that in STE in all sectors (all six sectors P < 0.0001, Mann-Whitney U test). The IOP fluctuation over 5 years in STE was significantly less than that in MTE (P < 0.0001, Mann-Whitney U test).

Conclusions : The structure of the mGCIPL was better preserved in STE than in MTE, even when the IOPs during follow-up were similar.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×