Abstract
Purpose :
To compare changes in the macular ganglion cell layer and inner plexiform layer (mGCIPL) thickness over 5 years between surgically treated eyes (STE) and medically treated eyes (MTE) with advanced glaucoma.
Methods :
We retrospectively investigated 86 patients comprising 43 with advanced open angle glaucoma (OAG) with trabeculectomy and 43 with medically treated OAG. The mGCIPL thickness was measured more than 5 times during follow-up by optical coherence tomography.
Results :
The mean age at study initiation was 62.5 ± 9.2 years in STE and 62.7 ± 9.5 years in MTE. The averaged mean deviation (MD) according to the Humphrey Field Analyzer central program 30-2 was -18.65 ± 4.76 dB in STE and -18.38 ± 4.19 dB in MTE at the first observation (P = 0.983; Mann-Whitney U test). The mGCIPL thickness in each sector showed no significant differences at initial measurement. The averaged intraocular pressure (IOP) throughout follow-up was 10.5 ± 2.0 mmHg in STE and 10.8 ± 0.8 mmHg in MTE (P = 0.429; Mann-Whitney U test). There was no significant difference in the MD changes over 5 years between the two groups (P = 0.405; Mann-Whitney U test). Changes in the mGCIPL thickness over 5 years in MTE were significantly greater than that in STE in all sectors (all six sectors P < 0.0001, Mann-Whitney U test). The IOP fluctuation over 5 years in STE was significantly less than that in MTE (P < 0.0001, Mann-Whitney U test).
Conclusions :
The structure of the mGCIPL was better preserved in STE than in MTE, even when the IOPs during follow-up were similar.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.