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Masahiro Onda, Akira Sawada, Hiroko Inuzuka, Tetsuya Yamamoto; Comparison of changes in mGCIPL thickness between medically and surgically treated eyes with advanced glaucoma. Invest. Ophthalmol. Vis. Sci. 2018;59(9):462. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To compare changes in the macular ganglion cell layer and inner plexiform layer (mGCIPL) thickness over 5 years between surgically treated eyes (STE) and medically treated eyes (MTE) with advanced glaucoma.
We retrospectively investigated 86 patients comprising 43 with advanced open angle glaucoma (OAG) with trabeculectomy and 43 with medically treated OAG. The mGCIPL thickness was measured more than 5 times during follow-up by optical coherence tomography.
The mean age at study initiation was 62.5 ± 9.2 years in STE and 62.7 ± 9.5 years in MTE. The averaged mean deviation (MD) according to the Humphrey Field Analyzer central program 30-2 was -18.65 ± 4.76 dB in STE and -18.38 ± 4.19 dB in MTE at the first observation (P = 0.983; Mann-Whitney U test). The mGCIPL thickness in each sector showed no significant differences at initial measurement. The averaged intraocular pressure (IOP) throughout follow-up was 10.5 ± 2.0 mmHg in STE and 10.8 ± 0.8 mmHg in MTE (P = 0.429; Mann-Whitney U test). There was no significant difference in the MD changes over 5 years between the two groups (P = 0.405; Mann-Whitney U test). Changes in the mGCIPL thickness over 5 years in MTE were significantly greater than that in STE in all sectors (all six sectors P < 0.0001, Mann-Whitney U test). The IOP fluctuation over 5 years in STE was significantly less than that in MTE (P < 0.0001, Mann-Whitney U test).
The structure of the mGCIPL was better preserved in STE than in MTE, even when the IOPs during follow-up were similar.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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