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Rei Nemoto, Yoshihiko Usui, Shunichiro Ueda, Hiroshi Goto; Immunophenotypic profiles of inflammatory cells in chalazion.. Invest. Ophthalmol. Vis. Sci. 2018;59(9):511.
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© ARVO (1962-2015); The Authors (2016-present)
The pathological mechanisms of chalazion remain unclear. There is no report on the profiles of inflammatory cells in this inflammatory conditions. We used flow cytometry to analyze the patterns of surface antigen expression on infiltrating cells in order to identify the specific immunophenotypic profiles of the inflammatory cells in chalazion.
Twenty three patients with chalazion who underwent surgical resection in our department were studied. Flow cytometry was used to analyze the specimens obtained at surgical removal for the expression of T cell surface antigens (CD3, CD4, CD8, CD25, CD30), B cell surface antigens (CD19, CD20, CD23), plasma cell surface antigens (CD138), natural killer cell surface antigens (CD16, CD56), macrophage surface antigens (CD11b), dendritic cell surface antigens (CD11c), and stem cell surface antigens (CD34).
In chalazion, the proportion of cells expressing T cell surface antigen (CD3) was significantly higher (p<0.0001) than those expressing other cell surface antigens. The proportion of CD4 positive T cells was significantly higher than that of CD8 positive T cells (p=0.0001).
Although various inflammatory cells are involved in the pathology of chalazion, this study suggests that a significantly higher proportion of CD4 positive T cells may be closely related to the pathological mechanisms of chalazion.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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