July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Pupillary response dynamics of mydriasis measured with multifocal pupillography.
Author Affiliations & Notes
  • Bhim Bahadur Rai
    Neuroscience, John Curtin School of Medical Research, Australian National University, Building 131, Garran Road, Acton, ACT, Australia 2601., Canberra, Australian Capital Territory, Australia
  • Faran Sabeti
    Neuroscience, John Curtin School of Medical Research, Australian National University, Building 131, Garran Road, Acton, ACT, Australia 2601., Canberra, Australian Capital Territory, Australia
    Optometry, University of Canberra, Canberra, Australian Capital Territory, Australia
  • Corinne F Carle
    Neuroscience, John Curtin School of Medical Research, Australian National University, Building 131, Garran Road, Acton, ACT, Australia 2601., Canberra, Australian Capital Territory, Australia
  • Ozge Sarac
    Ophthalmology, Yildirim Beyazit University, Ankara, Turkey
  • Emilie Rohan
    Neuroscience, John Curtin School of Medical Research, Australian National University, Building 131, Garran Road, Acton, ACT, Australia 2601., Canberra, Australian Capital Territory, Australia
  • Ted Maddess
    Neuroscience, John Curtin School of Medical Research, Australian National University, Building 131, Garran Road, Acton, ACT, Australia 2601., Canberra, Australian Capital Territory, Australia
  • Footnotes
    Commercial Relationships   Bhim Rai, None; Faran Sabeti, None; Corinne Carle, nuCoria (F), nuCoria (I), nuCoria (P); Ozge Sarac, None; Emilie Rohan, None; Ted Maddess, EyeCo (I), nuCoria (F), nuCoria (I), nuCoria (P)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 621. doi:
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      Bhim Bahadur Rai, Faran Sabeti, Corinne F Carle, Ozge Sarac, Emilie Rohan, Ted Maddess; Pupillary response dynamics of mydriasis measured with multifocal pupillography.. Invest. Ophthalmol. Vis. Sci. 2018;59(9):621.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Multifocal pupillography is potentially limited by the need for mydriasis for ocular examinations. We examined the time course and pupil response dynamics of mydriasis.

Methods : Normal participants were confirmed by a slit-lamp exam, Matrix visual fields, macular and retinal nerve fibre layer OCT. Pupil responses of 26 participants were recorded with video cameras under infrared illumination. The stimuli extended form fixation to ±30°, shown at 150 cd/m2 on a 10 cd/m2 background. The dichoptic stimuli comprised 44 independent stimulus regions/eye with a mean stimulus interval of 4 seconds/region. Predilation mfPOP was done, followed by post-dilation tests at 1, 2, 4, 6, 8, 12, 24 and 48 hours. A linear mixed effects model was fitted to contraction amplitudes and time to peak responses to determine the independent effects of mydriasis on mfPOP.

Results : Significant extra delays were recorded at 2 hrs post dilation (15.8 ± 1.2 ms, P < 0.00001). Response delays peaked at 4 hrs (31.0 ± 1.1 ms, P < 0.00001) and thereafter quickened towards baseline delays at 24 hrs. Amplitudes were more affected than delays with significant losses presenting at 4 hrs (4.0 ± 0.18 dB, P < 0.00001). Pupil response amplitudes increased towards baseline after 24 hrs, however amplitudes rebounded to significant losses at 48 hrs.

Conclusions : Pupillary response dynamics to mydriasis demonstrated that amplitudes were more affected than response delays and peaked at 24 and 4 hrs, respectively and did not recover to baseline until 48 and 12 hrs.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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