July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Monozygotic Twin Correlations of Retinal and Cerebral Vascular Parameters
Author Affiliations & Notes
  • Aleid van de Kreeke
    Ophthalmology, VU University Medical Center, Amsterdam, Netherlands
  • Ton Nguyen
    Ophthalmology, VU University Medical Center, Amsterdam, Netherlands
  • Elles Konijnenberg
    Alzheimercenter, VU University Medical Center, Amsterdam, Netherlands
  • Anouk Den Braber
    Alzheimercenter, VU University Medical Center, Amsterdam, Netherlands
  • Mara ten Kate
    Alzheimercenter, VU University Medical Center, Amsterdam, Netherlands
  • Pieter Jelle Visser
    Alzheimercenter, VU University Medical Center, Amsterdam, Netherlands
  • Frank D Verbraak
    Ophthalmology, VU University Medical Center, Amsterdam, Netherlands
  • Footnotes
    Commercial Relationships   Aleid van de Kreeke, None; Ton Nguyen, None; Elles Konijnenberg, None; Anouk Den Braber, None; Mara ten Kate, None; Pieter Jelle Visser, None; Frank Verbraak, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 627. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Aleid van de Kreeke, Ton Nguyen, Elles Konijnenberg, Anouk Den Braber, Mara ten Kate, Pieter Jelle Visser, Frank D Verbraak; Monozygotic Twin Correlations of Retinal and Cerebral Vascular Parameters. Invest. Ophthalmol. Vis. Sci. 2018;59(9):627.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : As a protrusion from the brain, the retina might reflect (pathological) changes in the brain. There is increasing evidence of retinal microvasculopathy correlating to cerebral small vessel disease (SVD) on MRI. This study compares ocular vascular parameters and SVD in a population of twins.

Methods : 210 (105 monozygotic twin pairs) cognitively healthy individuals (ages 60-100) underwent MRI, fundus photography and optical coherence tomography (OCT). Microbleeds and white matter hyperintensities (WMH, Fazekas score) were visually scored on MRI. Additionally, WMH volume was obtained using FreeSurfer. Fundus images were acquired from both eyes and analyzed using Singapore I Vessel Assessment (SIVA) to obtain 7 retinal vascular parameters (RVPs). Enhanced depth imaging OCT scans from both eyes were used to measure choroid thickness (CT) manually. Ophthalmological data were averaged over both eyes. The intrapair correlations for RVPs, CT and SVD parameters were obtained and relations between RVPs/CT and microbleeds/WMH (Fazekas score and volume) were investigated.

Results : Intra-twinpair correlations were high for all parameters: 0.553-0.782 (p<0.001 in all cases) for RVPs, 0.834 (p<0.001) for CT and 0.335-0.851 (p≤0.001 in all cases) for SVD parameters.
No correlations were found between RVPs and microbleeds or Fazekas score. Only increased venular tortuosity was related to increased total WMH (r=0.197, p=0.019). This remained significant even after correction for age, gender, total intracranial volume and hypertension. CT was not related to microbleeds, Fazekas score or WMH volume.

Conclusions : High intra-twinpair correlations for RVPs, CT and SVD markers were found in monozygotic twins, suggesting a high genetic contribution in these vascular parameters. However, only increased retinal venular tortuosity was found to be related to WMH volume on MRI, suggesting retinal vasculature shows little correlation to cerebral small vessel disease despite the high genetic influence on both. The lack of such correlations may be due to the relatively healthy nature of our study population (few people had significant SVD on MRI).

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×