July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Violet light exposure suppresses refractive change and axial elongation in a murine model of lens-induced myopia
Author Affiliations & Notes
  • Toshihide Kurihara
    Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Laboratory of Photobiology, Keio University School of Medicine, Tokyo, Japan
  • Xiaoyan Jiang
    Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Laboratory of Photobiology, Keio University School of Medicine, Tokyo, Japan
  • Kiwako Mori
    Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Laboratory of Photobiology, Keio University School of Medicine, Tokyo, Japan
  • Shin-cihi Ikeda
    Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Laboratory of Photobiology, Keio University School of Medicine, Tokyo, Japan
  • Hidemasa Torii
    Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Laboratory of Photobiology, Keio University School of Medicine, Tokyo, Japan
  • Kazuo Tsubota
    Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Toshihide Kurihara, Application no. 2017-41349 (P), PCT/JP2015/65997 (P), RestoreVision, Inc (I), Tsubota Laboratory, Inc (I), Tsubota Laboratory, Inc (F); Xiaoyan Jiang, Application no. 2017-41349 (P); Kiwako Mori, None; Shin-cihi Ikeda, Application no. 2017-41349 (P); Hidemasa Torii, PCT/JP2015/65997 (P), Tsubota Laboratory, Inc (I); Kazuo Tsubota, Application no. 2017-41349 (P), PCT/JP2015/65997 (P), RestoreVision, Inc (I), Tsubota Laboratory, Inc (I), Tsubota Laboratory, Inc (F)
  • Footnotes
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Investigative Ophthalmology & Visual Science July 2018, Vol.59, 677. doi:
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      Toshihide Kurihara, Xiaoyan Jiang, Kiwako Mori, Shin-cihi Ikeda, Hidemasa Torii, Kazuo Tsubota; Violet light exposure suppresses refractive change and axial elongation in a murine model of lens-induced myopia. Invest. Ophthalmol. Vis. Sci. 2018;59(9):677.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : We reported that violet light (VL, 360nm-400nm) may prevent myopia progression in chicks and human beings (Torii et al. EBioMedicine. 2017, Torii et al. Sci Rep. 2017). Here we examine whether VL can prevent myopia progression in a murine model of lens-induced myopia (LIM).

Methods : For LIM, twenty of 3-week-old wild-type C57BL/6J mice were attached with 0 diopter (D) lenses on the left eyes and -20 D lenses on the right eyes by mounting a frame on their skull using a self-cure dental adhesive system. Mice were then divided into two groups kept under different light conditions for 3 weeks: Control group (n = 8) and VL group (n = 12). For Control group, mice were kept in cages with white fluorescent lamp light only (50 lux) as a background light from 8:00 am to 8:00 pm. For VL group, together with the condition of Control group, three hours of VL (peak at 380nm, 400 μw/cm2) irradiation was added from 8:00 pm to 11:00 pm every day. The refractive state and axial length were measured before and after LIM. An infrared photorefractor (Steinbeis Transfer Center, Germany) was used to measure the refractive state. The axial length was analyzed by a SD-OCT system (Envisu R4310, Leica, Germany) under general anesthesia by the combination of midazolam, medetomidine and butorphanol tartrate.

Results : Myopia progression was significantly suppressed in VL group compared with Control group in both interocular refraction changes (D, Control vs VL, average ± standard deviation: -21.670 ± 10.250 vs -8.502 ± 5.971, p = 0.002) and interocular axial length changes (mm, 0.039 ± 0.019 vs 0.002 ± 0.032, p = 0.009).

Conclusions : We found that 3 hours of VL irradiation per day can suppress myopia progression in a murine model of LIM. This result indicates that VL has a therapeutic effect against myopia across species.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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