July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Organization and function of feedback connections in early visual processing
Author Affiliations & Notes
  • Alessandra Angelucci
    University of Utah, Salt Lake City, Utah, United States
  • Footnotes
    Commercial Relationships   Alessandra Angelucci, None
  • Footnotes
    Support  NIH Grants R01 EY026812, R01 EY019743, BRAIN U01 NS09970. NSF Grants IOS 1355075, EAGER 1649923. University of Utah Neuroscience Initiative Grant. Research to Prevent Blindness, Inc. Grant to the Dept. of Ophthalmology, Univ. of Utah
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 760. doi:https://doi.org/
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      Alessandra Angelucci; Organization and function of feedback connections in early visual processing. Invest. Ophthalmol. Vis. Sci. 2018;59(9):760. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Presentation Description : In the primate visual cortex, information travels along feedforward connections through a hierarchy of areas. Neuronal receptive fields in higher areas become tuned to increasingly complex stimulus features, via convergent feedforward inputs from lower areas. In turn, anatomically prominent feedback connections send information from higher to lower areas. Feedback connections have been implicated in many important functions for vision, including attention, expectation, and visual context, yet their anatomy and function have remained unknown. This is partly due technical difficulties of selectively labeling and manipulating the activity of feedback neurons. To overcome these technical limitations, we have used novel viral labeling and optogenetic approaches to investigate the anatomy and function of feedback connections between the secondary (V2) and the primary (V1) visual areas of primates. We find evidence for the existence of multiple anatomically and functionally distinct feedback channels. Moreover, our results point to a fundamental role of feedback in early visual processing, controlling the spatial resolution of visual signals, by modulating receptive field size, the perceptual sensitivity to image features, by modulating response gain, and contributing to contextual modulation in V1.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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