July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Risk factors for breakthrough vitreous hemorrhage after intravitreal anti-VEGF injection in age-related macular degeneration
Author Affiliations & Notes
  • Yong-Il Shin
    Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Korea (the Republic of)
  • Jae-Yun Sung
    Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Korea (the Republic of)
  • Jung-Yeul Kim
    Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Yong-Il Shin, None; Jae-Yun Sung, None; Jung-Yeul Kim, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 812. doi:
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      Yong-Il Shin, Jae-Yun Sung, Jung-Yeul Kim; Risk factors for breakthrough vitreous hemorrhage after intravitreal anti-VEGF injection in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2018;59(9):812.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the risk factors for breakthrough vitreous hemorrhage (VH) after intravitreal anti-vascular endothelial growth factor (anti-VEGF) injection in age-related macular degeneration (AMD) with submacular hemorrhage.

Methods : We retrospectively reviewed the medical records of patients diagnosed as AMD with submacular hemorrhage from January 2008 to January 2017. 29 patients with breakthrough VH after intravitreal anti-VEGF injection in AMD with submacular hemorrhage were enrolled. An age- and sex-matched control group patients were obtained who did not developed breakthrough VH after intravitreal anti-VEGF injection. We compared past medical history, anticoagulant medication, visual acuity, subtype of AMD, type of anti VEGF-agent, and size of submacular hemorrhage to identify possible risk factors between two groups.

Results : The mean age was 70.4 ± 10.9 years in breakthrough VH group. In 29 patients, 6 patients were diagnosed as choroidal neovascularization(CNV), 22 patients were diagnosed as polypoidal choroidal vasculopathy(PCV) and 1 patients were diagnosed as retinal angiomatous proliferation(RAP). PCV was associated with a significantly higher incidence of VH (odds ratio, 14.91; p=0.001). The size of submacular hemorrhage was 23.69 ± 12.19 disc area (DA) in breakthrough VH group and 5.45 ± 6.93 DA in control group. The size of submacular hemorrhage was significantly positively related to the occurrence of VH (p<0.001). The risk of vitreous hemorrhage was significantly higher when anticoagulants were administered (p=0.004). There were no significant difference between the type of anti-VEGF agent.

Conclusions : Taking anticoagulant medication, large-diameter submacular hemorrhage and PCV subtype were risk factors for breakthrough VH after anti-VEGF injection

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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