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Ik Soo Byon, Hanjo Kwon, Sungwho Park, Ji Eun E Lee; Assessment of Fluorescein Angiographic Pattern and Its prognostic value in Idiopathic Epiretinal Membrane. Invest. Ophthalmol. Vis. Sci. 2018;59(9):842.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate a fluorescein angiographic pattern and its association with visual outcome in idiopathic epiretinal membrane (ERM) removal.
This study was nonrandomized, retrospective, comparative, interventional case series. Idiopathic ERM patients with visual acuity of 20/200 to 20/30, intact ellipsoid zone (EZ), and postoperative follow-up of 6 months were included. Fluorescein angiography (FA) was conducted at baseline. Optical coherence tomography (OCT) was assessed at baseline and follow-up visits. Baseline FA pattern in macula and changes in visual acuity (VA) and OCT findings after ERM removal were evaluated.
Of total 46 eyes, 22 eyes (47.8 %) showed hyper-fluorescein of macula in mid-phase FA (Leak group). Their baseline parameters including VA and central macular thickness (CMT) were not different from eyes without leakage (Non-Leak group, n=24), except the inner retinal layer on fovea (IRLF) (11 vs 19, p= 0.004). The Leak group showed the worse VA (logMAR) (0.23 vs 0.12, p = 0.038) and thicker CMT (376.52 vs 316.39 μm, p = 0.007) at 6 months. Logistic regression analysis showed that the baseline FA pattern and VA were associated with final VA ≥ 20/25 (p = 0.028 and p = 0.019, respectively).
Approximately a half of idiopathic ERM patients showed a leakage of macula in FA. This FA pattern indicated the advanced damage in the inner retinal layers and provided a predictive value for visual prognosis after ERM removal.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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