Abstract
Purpose :
Recent studies have shown that the assessment of the macular ganglion cell layer measured by OCT could be an important method for the evaluation of glaucomatous damage or optic neuropathy. However, there have been few studies about its normative data of children. So we performed this study to identify the normative values of ganglion cell-inner plexiform layer (GCIPL) thickness in healthy Korean children using swept-source optical coherence tomography (SS-OCT, DRI OCT Triton®; Topcon, Japan) and to investigate correlations with age, refractive error, axial length (AL), retinal nerve fiber layer (RNFL) thickness and cup-to-disc (C/D) ratio.
Methods :
Healthy children aged between 3 and 18 who had visited our pediatric ophthalmology clinic between December 2015 and March 2017 were enrolled. Each subject underwent full ophthalmic examinations including RNFL thickness, C/D ratio and GCIPL thickness measurement by SS-OCT as well as AL measurement by partial-coherence interferometry (Lenstar LS-900®; Haag-Streit AG, Switzerland). We investigated the normative values of average and sectorial GCIPL thicknesses and evaluated the effect of age, spherical equivalent (SE), AL, RNFL thickness and C/D ratio on average GCIPL thickness using regression analysis with mixed models.
Results :
A total of 254 eyes of 127 children were included (62 males and 65 females). The mean age was 9.52 ± 3.79 years, and the mean SE -1.19 ± 3.08 D (range, -12.00 to +7.25 D). The mean AL was 23.27 ± 0.90 mm, and the mean average RNFL thickness 107.63 ± 12.51 μm. The mean area C/D ratio was 0.33 ± 0.17, horizontal C/D ratio 0.55 ± 0.16, and vertical C/D ratio 0.52 ± 0.16. The mean average GCIPL thickness was 71.56 ± 5.35 μm; the thickest sector was the superonasal (75.11 ± 5.72 μm) and the thinnest the inferior (66.77 ± 5.95 μm). According to multivariate regression analysis, average GCIPL thickness was significantly associated with SE and average RNFL thickness (P < 0.0001 for both): the higher the myopia or the thinner the RNFL thickness, the thinner the GCIPL thickness.
Conclusions :
This study provides an SS-OCT-based pediatric normative database of GCIPL thickness that can serve as a reference for early detection of and follow-up on glaucoma and other optic nerve diseases in children.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.