July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Correlations between dry eye, ocular surface findings, autonomic and sensitive neuropathy in diabetic patients with Charcot Joint Disease
Author Affiliations & Notes
  • Alex Treiger Grupenmacher
    Ophtalmology, University of Campinas, Campinas, SP, Brazil
  • Gabriel Ayub
    Ophtalmology, University of Campinas, Campinas, SP, Brazil
  • Yeelen Ballesteros Atala
    Endocrinology, University of Campinas, Campinas, SP, Brazil
  • Jessica Castro
    Endocrinology, University of Campinas, Campinas, SP, Brazil
  • Marina Gonçalves Monteiro Viturino
    Ophtalmology, University of Campinas, Campinas, SP, Brazil
  • Delma Huarachi
    Ophtalmology, University of Campinas, Campinas, SP, Brazil
  • Daniel Borges
    Ophtalmology, University of Campinas, Campinas, SP, Brazil
  • Bruna Gil Ferreira
    Ophtalmology, University of Campinas, Campinas, SP, Brazil
  • Bruna Duarte
    Ophtalmology, University of Campinas, Campinas, SP, Brazil
  • Maria Candida Ribeiro Parisi
    Endocrinology, University of Campinas, Campinas, SP, Brazil
  • Monica Alves
    Ophtalmology, University of Campinas, Campinas, SP, Brazil
  • Footnotes
    Commercial Relationships   Alex Treiger Grupenmacher, None; Gabriel Ayub, None; Yeelen Ballesteros Atala, None; Jessica Castro, None; Marina Viturino, None; Delma Huarachi, None; Daniel Borges, None; Bruna Ferreira, None; Bruna Duarte, None; Maria Candida Ribeiro Parisi, None; Monica Alves, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 931. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Alex Treiger Grupenmacher, Gabriel Ayub, Yeelen Ballesteros Atala, Jessica Castro, Marina Gonçalves Monteiro Viturino, Delma Huarachi, Daniel Borges, Bruna Gil Ferreira, Bruna Duarte, Maria Candida Ribeiro Parisi, Monica Alves; Correlations between dry eye, ocular surface findings, autonomic and sensitive neuropathy in diabetic patients with Charcot Joint Disease. Invest. Ophthalmol. Vis. Sci. 2018;59(9):931.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Dry Eye Disease (DED) has a complex pathophysiology, which has been build up on knowledge that, among others, impaired peripheral sensisitivity, neuroautonomic disorders and inflammation act as pivotal mechanisms. Charcot Joint Disease (CJ), a rare and late diabetic complication, shares these similar pathological background with DED, being notoriuos for the severe peripheral sensitivity impairment (PSI) and autonomic cardiovascular neuropathy (ACP). The aim of this study was to assess diagnosis and severity of DED in a group of CJ patients correlating the neurosensory disorders trough PSI and ACP evaluation with ocular surface involvement

Methods : 15 diabetic patients diagnosed with CJ were assessed on prevalence and severity of PSI and ACP. Ocular surface evaluantion and DED were investigated with OSDI questionnaire, non-invasive break-up time, lacrimal meniscus height, surface hyperemia, meiobomiography, Schrimer 1 test, fluorescein and lissamine green staining. Ancilliary evaluation was performed with pupilogram. All results were compared with a diabetic group without CJ

Results : 86% of the patients presented with DED, with mean disease classified as mild/moderate. Diabetic retinopathy was observed in 85% of patients. Pupilogram measures were statistically lower in CJ patients than in control group (min size 1.66 vs 2.76mm p<0.05; mean 2,76 vs 5,28mm p<0.0001; max 3.41 vs 6.10mm p<0.0001; SD of contraction was 0,12 vs 0,67 p<0.0001). Strongest correlation between PSI and DED were found in fluorescein score and meiobomiography score. Strongest correlation between ACP and DED were found in amplitude of pupillometry.

Conclusions : Patients with CJ showed a higher prevalence of DED than both non-diabetic and diabetic population without CJ. Puppilogram measures were lower in CJ patients than in control group, which suggests association between sistemic and ocular neuroautonomic impairment

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×