July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Assessment of the outflow drainage system in AMD after multiple anti-VEGF intravitreous injections
Author Affiliations & Notes
  • Pedro C Carricondo
    Ophthalmology Department, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil
  • Leandro C Zacharias
    Ophthalmology Department, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil
  • Taurino Rodrigues
    Ophthalmology Department, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil
  • Larissa Y Yagaeshi
    Ophthalmology Department, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil
  • Sergio Luis G Pimentel
    Ophthalmology Department, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil
  • Maria Fernanda Abalem
    Ophthalmology Department, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil
    Ophthalmology and Vision Sciences, University of Michigan, Ann Arbor, Michigan, United States
  • C Gustavo De Moraes
    Ophthalmology Department, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil
    Opthalmology and Vision Science, Columbia University, New York, New York, United States
  • Remo Susanna
    Ophthalmology Department, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil
  • Footnotes
    Commercial Relationships   Pedro Carricondo, Abbott (S), Alcon (R), Alcon (C), Allergan (S), Bausch & Lomb (R), Bausch & Lomb (C), Bayer (R), Bayer (C), Novartis (R), Novartis (C); Leandro Zacharias, None; Taurino Rodrigues, None; Larissa Yagaeshi, None; Sergio Luis Pimentel, None; Maria Fernanda Abalem, None; C Gustavo De Moraes, None; Remo Susanna, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 1470. doi:
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    • Get Citation

      Pedro C Carricondo, Leandro C Zacharias, Taurino Rodrigues, Larissa Y Yagaeshi, Sergio Luis G Pimentel, Maria Fernanda Abalem, C Gustavo De Moraes, Remo Susanna; Assessment of the outflow drainage system in AMD after multiple anti-VEGF intravitreous injections. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1470.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Sustained elevated IOP has been reported with all anti-VEGF agents used in ophthalmology and even among patients without prior history of glaucoma or ocular hypertension. Numerous potential mechanisms have been suggested to explain this phenomenon, many of them related to drainage system damage.
The key application of the WDT today is as a stress test that aims to identify sub-clinical abnormalities of the eye’s outflow facility as an indirect measure of the drainage system.
The aim of this study is to evaluate the outflow facility after multiple intravitreous injections of anti-VEGF agents and compare these results with their contralateral eye and eyes of normal, healthy controls who will not undergo the injection.

Methods : Twenty-six healthy control eyes and thirty-one patients with AMD that received at least 6 anti-VEGF intravitreous injections were selected. Only one eye from controls and AMD patients were included. If both eyes of AMD needed anti-VEGF injections, only one eye was randomly selected. Contra-lateral eyes of AMD patients wich not received any injections were included as a third group (fellow eye control).
The WDT was performed and Peak IOP was defined as the highest IOP measured during the WDT. IOP peaks and all IOP measurements were compared between eyes of control subjects, contralateral eyes of AMD patients, and AMD eyes.
Variables “baseline”, “time point” and “IOP peak” was analyzed with descriptive statistics: mean, standard deviation (SD), standard error (SE), median, minimum and maximum values, and 95% confidence interval (95% CI). Repeated measures analysis of variance (r-ANOVA) with time points (baseline, 15 min, 30 min and 45 min) were applied

Results : Baseline IOP measures were significantly higher in patients submited to multiple intravitreal injections, compared to controls and contralateral eyes.
The peak IOP and the difference between baseline and peak IOP were significantly higher in the intravitreal group.

Conclusions : Our results suggests that damage to outflow facility may play a role in the development of elevated IOP after multiple intravitreal injections of antiangiogenics.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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