July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Choroidal Nevus with Retinal Invasion in 8 Cases
Author Affiliations & Notes
  • Stephanie Weiss
    Drexel University College of Medicine, Richboro, Pennsylvania, United States
    Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Christina Stathopoulos
    Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Carol L Shields
    Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Footnotes
    Commercial Relationships   Stephanie Weiss, None; Christina Stathopoulos, None; Carol Shields, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 1502. doi:
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      Stephanie Weiss, Christina Stathopoulos, Carol L Shields; Choroidal Nevus with Retinal Invasion in 8 Cases. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1502.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : Choroidal nevus can cause overlying chronic retinal pigment epithelium (RPE) degenerative features but frank retinal invasion is exquisitely rare.

Methods : Retrospective review of 8 cases of choroidal nevus with retinal invasion with evaluation of clinical and imaging features.

Results : At time of diagnosis of choroidal nevus with retinal invasion, mean patient age was 65 years. Mean tumor basal diameter was 7 mm and mean thickness was 2.3 mm. Retinal invasion was ophthalmoscopically visible in all eyes. Related features included drusen (n=4/8) and RPE fibrous metaplasia (n=2/8). Overlying lipofuscin, subretinal fluid, RPE detachment, and retinal edema were absent. On B-scan ultrasonography, the lesion was dome-shaped (n=7/7) and echodense (n=6/7). Optical coherence tomography demonstrated outer retinal invasion (n=8/8) with additional inner retinal invasion (n=3/8). The tissue was hypo-autofluorescent at the site of invasion (n=6/7). Over mean follow-up of 40 months, tumor enlargement was detected in 2 eyes and managed with observation (<1 mm enlargement) or plaque radiotherapy (5 mm enlargement). Nevus hypo-autofluorescence was correlated with nevus stability (p=0.035).

Conclusions : Retinal invasion of choroidal nevus is rare. In this series of 8 cases, only one demonstrated transformation into melanoma over mean interval of 40 months. Long-term monitoring of such lesions is warranted.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.


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