July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Fundus Autofluorescence in Congenital Aniridia
Author Affiliations & Notes
  • Erlend Christoffer Sommer Landsend
    Department of Ophthalmology, Oslo University Hospital, Oslo, Norway
    Faculty of Medicine, University of Oslo, Oslo, Oslo, Norway
  • Øygunn Aass Utheim
    Department of Ophthalmology, Oslo University Hospital, Oslo, Norway
    Department of Medical Biochemistry, Oslo University Hospital, Oslo, Oslo, Norway
  • Hilde Rogeberg Pedersen
    National Centre for Optics, Vision and Eye Care, Faculty of Health and Social Sciences, University College of Southeast Norway, Kongsberg, Buskerud, Norway
  • Rigmor C Baraas
    National Centre for Optics, Vision and Eye Care, Faculty of Health and Social Sciences, University College of Southeast Norway, Kongsberg, Buskerud, Norway
  • Neil S Lagali
    Department of Clinical and Experimental Medicine, Linköping University, Linköping , Linköping, Sweden
  • Ragnheidur Bragadottir
    Department of Ophthalmology, Oslo University Hospital, Oslo, Norway
    Faculty of Medicine, University of Oslo, Oslo, Oslo, Norway
  • Morten C. Moe
    Department of Ophthalmology, Oslo University Hospital, Oslo, Norway
    Faculty of Medicine, University of Oslo, Oslo, Oslo, Norway
  • Tor Paaske Utheim
    Department of Ophthalmology, Oslo University Hospital, Oslo, Norway
    Department of Medical Biochemistry, Oslo University Hospital, Oslo, Oslo, Norway
  • Footnotes
    Commercial Relationships   Erlend Landsend, None; Øygunn Utheim, None; Hilde Rogeberg Pedersen, None; Rigmor Baraas, None; Neil Lagali, None; Ragnheidur Bragadottir, None; Morten Moe, None; Tor Utheim, None
  • Footnotes
    Support  Grant support has been received from: Dr. Jon S. Larsen’s foundation, the Inger Holm’s Memorial Fund, the Norwegian Association of the Blind and Partially Sighted, and from the Norwegian Ophthalmological Society in terms of Professor Hjalmar Schiötz Memorial Fund grants and grants for PhD in Strabismus/ Paediatric Ophthalmology.
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 1514. doi:https://doi.org/
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      Erlend Christoffer Sommer Landsend, Øygunn Aass Utheim, Hilde Rogeberg Pedersen, Rigmor C Baraas, Neil S Lagali, Ragnheidur Bragadottir, Morten C. Moe, Tor Paaske Utheim; Fundus Autofluorescence in Congenital Aniridia. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1514. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate fundus autofluorescence (FAF) and other fundus manifestations in a cohort of congenital aniridia in a matched case-control study.

Methods : Fourteen patients (9 females) with congenital aniridia and 14 age- and sex-matched healthy controls were examined. FAF pictures and color fundus photographs were obtained with an ultra-wide-field scanning laser ophthalmoscope (Optomap Panoramic 200Tx; FAF with 532 nm (green) laser, color images with combined 532 nm and 633 nm laser). FAF intensity was quantified in 1) central macula equivalent to the fovea and 2) the rest of macula corresponding to a ring surrounding fovea, and related to an internal reference in the picture. Fundus color images were evaluated subjectively and classified according to a three-degree scale (dark, normal, light). All aniridia subjects underwent an ophthalmological examination, including systematic slit-lamp biomicroscopy of anterior and posterior segment of the eye. Results from image analyses in aniridia patients were compared to matched controls, and correlated with other clinical findings in the aniridia group.

Results : In both aniridia and control group mean age was 28.4±15.0 yrs. (range 11–64 and 9–64 yrs., respectively). Mean ratio between FAF intensity in the fovea and the internal reference was 3.52±1.18 in aniridia patients and 3.10±0.70 in control subjects (p=0.334). Mean ratio between FAF intensity in the macular ring and fovea was 1.01±0.15 in aniridia vs. 1.18±0.09 in controls (p=0.034). Fovea could be defined by subjective assessment of FAF images in three aniridia patients (21.4%) and in all control subjects (p<0.001). Fundus color was staged as light in 12 aniridia patients, but in only one control (p<0.001). In aniridia, presence of macular hypoplasia evaluated by biomicroscopy correlated with lower ratio between FAF intensity in the macular ring and fovea (p=0.003), lack of foveal appearance by subjective analyses of FAF images (p=0.031), and observation of nystagmus (p=0.009).

Conclusions : Aniridia patients present a lower ratio between FAF intensity in the peripheral and central macula than healthy individuals. Presence of macular hypoplasia evaluated by biomicroscopy correlates with absence of foveal hypoautofluorescence assessed both objectively and subjectively. Hence, FAF imaging could be an additional tool in evaluation of macular function in aniridia.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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