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Danny Leung, Mitchell W Dul, George Comer, Michael Chaglasian, Elda Mehrabyan, Jeffrey Fischer, Murray Fingeret, Edmund Ng, Wei Chieh Huang, Charles Reisman; The development of a reference database with one-micron wavelength swept-source OCT DRI OCT Triton. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1523.
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To develop a normative reference database for a new generation one-micron wavelength Swept-Source (SS) OCT system, DRI OCT Triton.
This is a prospective, multicenter cohort study conducted at six clinical sites across the United States. A total of 410 subjects were enrolled in the study. All study eyes, which were healthy and randomly selected, were imaged with three default scan modes, 7x7 mm2 macula, 6x6 mm2 disc, and 12x9 mm2 wide scan modes. Macula full retinal thickness (FRT), ganglion cell plus inner plexiform layer thickness (GCL+), and ganglion cell complex thickness (GCL++) were measured from Macula and Wide scans. Circumpapillary retinal nerve fiber layer thickness (cpRNFL) and various optic disc parameters were measured from Disc, and Wide scans. 1st, 5th, 50th, 95th, and 99th percentiles for all measured parameters were estimated by non-crossing quantile regression. Age was the covariate for FRT, GCL+, and GCL++ measurements. Age and disc area were covariates for the cpRNFL and optic disc parameters measurements.
The mean (SD) age was 48.6 (16.7) years (ranged from 18 – 90 years). 47% of the subjects were male. Mean (SD) measurements (in mm) for the 12x9 mm2 wide scans were: central foveal thickness = 239.86 (20.97), average GCL+ = 70.91 (5.76), average GCL++ = 107.27 (7.94), and average cpRNFL = 106.35 (10.54). Age-related FRT, GCL+, GCL++, and cpRNFL changes were observed. Disc area had a more profound effect in optic disc parameters than age. These measurements are consistent with published data. The measurements of 7x7 mm2 macula and 6x6 mm2 disc scans were similar to corresponding 12x9 mm2 wide scan results.
The overall thickness values reported with the DRI OCT Triton were consistent with other studies where different OCT devices were used. The reference limits at the 1st, 5th, 95th, and 99th percentile points establish thresholds for quantitative comparison of macular and cpRNFL thickness as well as optic disc parameter measurements to a database of known healthy subjects.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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