July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Degenerative "senile" retinoschisis: Observations from Ultra-widefield imaging.
Author Affiliations & Notes
  • Aristomenis Thanos
    Retina, Legacy Devers Eye Institute, Portland, Oregon, United States
  • Bozho Todorich
    Pennsylvania Retina Specialists, Camp Hill, Pennsylvania, United States
    Associated Retinal Consultants, Royal Oak, Michigan, United States
  • Tahsin Khundkar
    New York Medical College , New York, New York, United States
  • Cindy Ung
    Massachusetts Eye & Ear Infirmary, Boston, Massachusetts, United States
  • Yoshihiro Yonekawa
    Massachusetts Eye & Ear Infirmary, Boston, Massachusetts, United States
  • Antonio Capone
    Associated Retinal Consultants, Royal Oak, Michigan, United States
  • George A. Williams
    Associated Retinal Consultants, Royal Oak, Michigan, United States
  • Jeremy D. Wolfe
    Associated Retinal Consultants, Royal Oak, Michigan, United States
  • Footnotes
    Commercial Relationships   Aristomenis Thanos, None; Bozho Todorich, None; Tahsin Khundkar, None; Cindy Ung, None; Yoshihiro Yonekawa, None; Antonio Capone, None; George Williams, None; Jeremy Wolfe, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 1532. doi:
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    • Get Citation

      Aristomenis Thanos, Bozho Todorich, Tahsin Khundkar, Cindy Ung, Yoshihiro Yonekawa, Antonio Capone, George A. Williams, Jeremy D. Wolfe; Degenerative "senile" retinoschisis: Observations from Ultra-widefield imaging.. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1532.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To explore the imaging characteristics, including ultra wide-field color fundus photography, autofluorescence and angiography of patients with senile retinoschisis (SR) using Optomap technology.

Methods : This is a multi-center, retrospective, non-comparative, consecutive case series of patients who were examined at four institutions. All patients underwent ultra-widefield fundus imaging (UWFI) using the Optos 200Tx or P200dTx imaging system. Inclusion criteria were presence of degenerative peripheral retinoschisis in either eye. Exclusion criteria included any evidence (by history or examination) of congenital X-linked retinoschisis, retinal detachment surgery, or retinal vascular disease causing retinal capillary nonperfusion, including diabetic retinopathy, familial exudative vitreoretinopathy, and sickle cell retinopathy.

Results : A total of 35 consecutive patients (58 eyes) with SR were identified who underwent 55 sessions of UWF imaging, including color fundus photography, fundus autofluorescence and fluorescein angiography. Ultra widefield fundus autofluorescence images illustrated the extent of the schisis cavity in 67% of cases with variable features. A crescent of hypo-autofluorescence was often evident at the edge of the schisis cavity aiding in its identification. A total of 31 UWF fluorescein angiograms (UWFFA) were reviewed and 90% of these studies illustrated abnormalities in the area affected by the schisis. The most common finding was retinal vascular leakage observed in 29 (93.5%) eyes.

Conclusions : UWF color fundus photography and fundus autofluorescence are reliable noninvasive tools that can aid in the diagnosis and objective monitoring of patients with SR.The breadth of retinal vascular abnormalities that were identified in areas of SR using UWF fluorescein angiography may indicate the presence of a vascular component in the pathogenesis of this condition.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.


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