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Don-Il Ham, Patrick Kim, Dong Hoon Shin, Byung Jae Kim, Mingui Kong; Peripheral Findings of Ultra-wide-field Angiography in Acute Vogt-Koyanagi-Harada Disease. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1533.
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To investigate the prevalence of peripheral abnormal findings of ultra-wide-field (UWF) angiography in comparison with the prevalence of central abnormal findings, and their correlation with clinical findings in acute Vogt-Koyanagi-Harada (VKH) disease.
Retrospective, observational study on 26 eyes of 13 patients with acute VKH disease who underwent UWF fluorescein angiography (FA). Sixteen eyes of 8 patients also underwent UWF indocyanine green angiography (ICGA). A circle simulating the central 75° field was used to divide the acquired image into the central fundus area (CFA) and the peripheral fundus area (PFA). The presence of six previously reported abnormal angiographic findings in the CFA and the PFA were analyzed, and correlation between peripheral angiographic findings with clinical findings were investigated.
All eyes demonstrated more than one abnormal angiographic finding in both the CFA and the PFA. UWF FA revealed three abnormal findings in the CFA versus the PFA: focal leakage (92.3% versus 76.9%), pooling with a dark rim (84.6% versus 53.8%), and retinal vascular leakage (0% versus 46.2%). UWF ICGA, revealed three abnormal findings in the CFA versus the PFA: hypofluorescent dots (100% versus 100%), leaking fuzzy choroidal vessels (93.8% versus 75.0%), and late hypofluorescent patches (81.3% versus 31.3%). Pooling with a dark rim was significantly associated with low initial visual acuity (P = 0.022).
Abnormal UWF angiographic findings were frequently detected in the PFA as well as in the CFA. Such findings may be useful in the evaluation and monitoring of VKH disease.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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