July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Effect of Topical Latanoprost on Choroidal Thickness in Guinea Pigs
Author Affiliations & Notes
  • Nevin El-Nimri
    Vision Science, UC Berkeley, Berkeley, California, United States
  • Liqin Jiang
    Vision Science, UC Berkeley, Berkeley, California, United States
  • Dinasha Dahanayake
    UC Berkeley , Berkeley , California, United States
  • Christine Frances Wildsoet
    Vision Science, UC Berkeley, Berkeley, California, United States
  • Footnotes
    Commercial Relationships   Nevin El-Nimri, None; Liqin Jiang, None; Dinasha Dahanayake, None; Christine Wildsoet, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 1578. doi:
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    • Get Citation

      Nevin El-Nimri, Liqin Jiang, Dinasha Dahanayake, Christine Frances Wildsoet; Effect of Topical Latanoprost on Choroidal Thickness in Guinea Pigs
      . Invest. Ophthalmol. Vis. Sci. 2018;59(9):1578.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the effect of latanoprost, an ocular hypotensive prostaglandin analog, on choroidal thickness and structure in young healthy guinea pigs.

Methods : Young (three-month-old) guinea pigs (n=3) underwent daily monocular treatment with 0.005% latanoprost for 2-weeks. Tonometry (iCare) and retinoscopy were undertaken to monitor IOP and refractive error (recorded as spherical equivalent values), respectively. Choroidal thickness (ChT) was measured using high frequency A-scan ultrasonography and posterior segment SD-OCT (Bioptigen), which also allowed Ch blood vessel (BV) area to be analyzed. Image J was used to analyze SD-OCT images.

Results : As expected, latanoprost significantly reduced IOP in treated eyes. Mean interocular IOP differences (± SE) changed from -0.44±0.48 mmHg at baseline to -2.89±1.13 mmHg at 2 weeks (p= 0.05). Latanoprost also induced significant choroidal thickening: mean interocular ChT differences, as measured by SD-OCT, changed from 72.44±6.23 to 80.22±10.08 µm (p<0.0001), with the BV area in the choroids of treated eye also increasing significantly, from 671.89±199.85 to 692.44±159.35 (p=0.0002). Refractive errors were unaffected; interocular differences changed from -0.71±0.80 to 0.25±0.63 D (p= 0.19).

Conclusions : Daily topical latanoprost administered to otherwise untreated young healthy guinea pigs resulted in choroidal thickening, with vascular changes at least partly accounting for this increase. The possibility that such choroidal changes underlie the inhibitory effect of latanoprost on myopia progression in young guinea pigs (El-Nimri et al, ARVO 2017) awaits further investigation.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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