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Renu A. Kowluru; Protecting mitochondrial homeostasis in diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1608.
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Presentation Description :
Mitochondria play central role in the development of diabetic retinopathy; their dysfunction initiates capillary cell apoptosis, a phenomenon which precedes the development of histopathology characteristic of diabetic retinopathy. Sustained free radical accumulation damages mitochondrial DNA, and impairs transcription of mtDNA, The electron transport system becomes overwhelmed, and continues to self-perpetuate vicious cycle of free radicals. Furthermore, systems to repair damaged mtDNA and scavenge free radicals also become dysfunctional. We will discuss the importance of mitochondrial homeostasis in diabetic retinopathy, and will also highlight the role of epigenetic modifications in maintaining mitochondrial integrity.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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