July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Lamina cribrosa microstructural analysis using OCT
Author Affiliations & Notes
  • Hiroshi Ishikawa
    Department of Ophthalmology, New York University , Edgewater, New Jersey, United States
  • Footnotes
    Commercial Relationships   Hiroshi Ishikawa, None
  • Footnotes
    Support  NIH R01-EY13178 and R01-EY25011
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 1615. doi:
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    • Get Citation

      Hiroshi Ishikawa; Lamina cribrosa microstructural analysis using OCT. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1615.

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      © ARVO (1962-2015); The Authors (2016-present)

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Presentation Description : Lamina cribrosa (LC) has become one of the very actively studied subjects recently. Technological advancement of optical coherence tomography (OCT) allows us to investigate its biomechanical characteristics in relation to potential glaucoma development/progression. Although OCT provides three-dimensional (3D) volume images, most of the studies are limited to two-dimensional and macrostructural analysis. We developed a microstructural analysis method utilizing the full 3D volume information and found non-linear complex biomechanical responses of LC by modulating both the intraocular and intracranial pressures on primate eyes. We also found that pore tortuosity may increase with glaucoma. In this presentation, various new findings on LC microstructural analysis will be discussed with its limitations as well as future outlook.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.


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