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Hiroshi Ishikawa; Lamina cribrosa microstructural analysis using OCT. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1615.
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Presentation Description :
Lamina cribrosa (LC) has become one of the very actively studied subjects recently. Technological advancement of optical coherence tomography (OCT) allows us to investigate its biomechanical characteristics in relation to potential glaucoma development/progression. Although OCT provides three-dimensional (3D) volume images, most of the studies are limited to two-dimensional and macrostructural analysis. We developed a microstructural analysis method utilizing the full 3D volume information and found non-linear complex biomechanical responses of LC by modulating both the intraocular and intracranial pressures on primate eyes. We also found that pore tortuosity may increase with glaucoma. In this presentation, various new findings on LC microstructural analysis will be discussed with its limitations as well as future outlook.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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