July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
DARC and Glaucoma
Author Affiliations & Notes
  • M Francesca Cordeiro
    Glaucoma & Retinal Neurodegnrtn Res Grp, UCL Inst Ophthal & Western Eye Hsp London, London, United Kingdom
    Ophthalmology, Imperial College London, LONDON, London, United Kingdom
  • Footnotes
    Commercial Relationships   M Francesca Cordeiro, Allergan (C), Santen (R), Sooft (R), Thea (R), UCL (P)
  • Footnotes
    Support  Wellcome Trust WT099729
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 1617. doi:
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    • Get Citation

      M Francesca Cordeiro; DARC and Glaucoma. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1617.

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      © ARVO (1962-2015); The Authors (2016-present)

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Presentation Description : Retinal imaging provides an opportunity to visualize in vivo processes in a non-invasive manner that is not easily possible in the rest of the body. Increasingly it is recognized that imaging may potentially be useful in determining cellular function in the intact eye in vivo. DARC (Detection of Apoptosing Retinal Cells) is a newly developed technology that identifies apoptosing retinal cells through the use of an intravenously administered fluorescent biomarker and confocal scanning ophthalmoscopy. Results from a Phase I clinical trial showed it to be safe and well-tolerated. In glaucoma, levels of retinal cell apoptosis were significantly increased compared with healthy controls and predicted future disease progression. Although further clinical trials are underway, including Phase II studies in glaucoma, optic neuritis, Down syndrome, and age-related macular degeneration, and validation is needed, early results suggest DARC may have potential in the early detection and management of glaucoma.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.


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