July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Frequency of atypical vascularization during IAC for retinoblastoma
Author Affiliations & Notes
  • Jacob Pe'er
    Ophthalmology, Hadassah-Hebrew Univ Med Ctr, Jerusalem, Israel
  • Nadav Levinger
    Ophthalmology, Hadassah-Hebrew Univ Med Ctr, Jerusalem, Israel
  • Jose Cohen
    Neurosurgery, Hadassah-Hebrew University Medical Center, Jerusalem, N/A, Israel
  • Shahar Frenkel
    Ophthalmology, Hadassah-Hebrew Univ Med Ctr, Jerusalem, Israel
  • Footnotes
    Commercial Relationships   Jacob Pe'er, None; Nadav Levinger, None; Jose Cohen, None; Shahar Frenkel, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 1643. doi:
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      Jacob Pe'er, Nadav Levinger, Jose Cohen, Shahar Frenkel; Frequency of atypical vascularization during IAC for retinoblastoma. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1643.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : Intra-arterial chemotherapy (IAC) in the treatment of retinoblastoma is administered at the osteum of the ophthalmic artery to deliver a high dose of chemotherapy to the eye. In some cases, injection of dye through the intra-arterial catheter does not demonstrate the classic choroidal flush and the drug needs to be administered through branches of the external carotid artery. The purpose of this study was to evaluate the arterial anatomy around the eye of children with retinoblastoma in a referral center in Israel.

Methods : A cohort of children with retinoblastoma was treated with IAC as a primary or secondary treatment. The angiograms were reviewed and the main vessel supplying the eye was noted.

Results : Ten children were treated with a mean of 1.8 treatments per child. In five the Ophthalmic artery was open, and in five an alternative route was required for drug administration. In two cases when the IAC was repeated the ophthalmic artery was occluded and an alternative route was required. In one of these two cases, a third treatment showed some opening of the ophthalmic artery which allowed treatment through what previously appeared to be a closed artery.

Conclusions : Our findings in the Israeli population match those of the MSKCC group that in many cases IAC needs to be delivered through collateral vessels and not from the internal carotid into the ophthalmic artery.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.


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