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Rachel L Redfern, Jason J Nichols, Wolfgang Sickenberger, Jennifer Swingle Fogt, Marc Schulze, Christopher Lievens, Loretta Szczotka-Flynn, Stefan Schwarz, Amanda Shows, Jessie M Lemp; Ex vivo analysis of lipid deposition with silicone hydrogel contact lenses and EOBO-based lens care solutions. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1768.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the cholesterol deposition profile of a regimen of lotrafilcon B lenses packaged in blister solution containing the EOBO (polyoxyethylene-polyoxybutylene) wetting agent (AIR OPTIX plus HydraGlyde, AOHG) and lens care solutions formulated with EOBO (OPTI-FREE PureMoist, OFPM or CLEAR CARE PLUS, CCP) with a regimen of marketed silicone hydrogel (SiHy) lenses and marketed multipurpose solutions (MPS) that do not contain EOBO.
Adult, habitual SiHy lens wearers and habitual MPS users participated in a multi-center, prospective, stratified, controlled, parallel-group, masked study. Subjects (n=252) were randomized to wear either AOHG or habitual SiHy lenses (Acuvue Oasys, Acuvue Vita, Biofinity, or Ultra) daily for 30 (+3) days. Subjects in the AOHG lens group were further randomized to use either OFPM or CCP to care for their lenses. Lenses were replaced according to the manufacturer recommendation for each lens material. Subjects assigned to habitual SiHy lenses continued to use their habitual multipurpose solution (HMPS). Lenses (n=20 to 28 per regimen) were collected for assessment of total cholesterol uptake. Cholesterol sorption was measured using a fluorometric enzymatic assay as previously described (Nash et al, E&CL 2014).
AOHG/CCP regimen demonstrated significantly less cholesterol uptake (median = 0.30 µg) than the following regimens: Biofinity/HMPS (median = 1.55 µg), Vita/HMPS (median = 4.20 µg), Ultra/HMPS (median = 1.90 mg) and Oasys/HMPS (median = 1.55 mg), (p < 0.0001 for all). Likewise, the AOHG/OFPM regimen had significantly less cholesterol uptake (median = 0.10 µg) than all habitual lens and solution regimens (p < 0.0001 for all).
The AOHG/CCP and AOHG/OFPM regimens resulted in less cholesterol sorption than each of the habitual SiHy/MPS regimens (p < 0.0001). Further research is necessary to understand the impact of cholesterol deposition on patient clinical outcomes.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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