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Jennie Diec, Jennifer Sha, Daniel Tilia, Monica Jong, Nisha Shirish Yeotikar, Varghese Thomas, Ravi Bakaraju; Visual performance of prototype extended depth-of-focus contact lenses against contact lenses used for myopia control. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1776. doi: https://doi.org/.
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Our research group has shown myopia control (MC) efficacy with 2 prototype extended depth-of-focus (EDOF1 & 2) contact lenses (CLs). This analysis assessed the visual performance (VP) of EDOF1 & 2 against commercial CLs used in MC
Non-presbyopic participants (n=35) wore the 2 EDOF CLs, Proclear Multifocal-Distance +2D (PCMF) and MiSight (MS) CLs for 1 week in a randomized, double-masked, cross-over clinical trial. Acuity-based VP was assessed after 1 week of wear. Measures comprised high and low contrast visual acuity (HCVA, LCVA; logMAR) at 6m, 70cm and 40cm and stereopsis at 40cm. Subjective VP was determined with a 1-10 numeric rating scale for vision clarity, vision stability, overall vision satisfaction, ghosting, driving vision, haloes at night and comfort. Willingness to purchase was assessed with a binary Yes/No response. Statistical analysis used linear mixed model with significance set at 5%.
MS was significantly better than both EDOF CLs for HCVA at 6m (<3 letters, p≤0.006), while PCMF and MS were significantly better than both EDOF CL for LCVA at 6m (1 line, p≤0.027). There were no significant differences between PCMF/MS and EDOF CLs for HCVA at 70cm (p=0.336), 40cm (p=0.232) and LCVA at 70cm (p=0.170) and 40cm (p=0.133). There was no difference between all CLs for stereopsis (p=0.598).Subjectively, both EDOF CLs were rated significantly higher than PCMF/MS for vision clarity (8.2±1.4, 7.7±1.5 v 7.2±1.8, 7.0±1.8, p≤0.001) and ghosting (9.0±1.3, 8.6±1.6 v 7.5±2.1, 6.7±2.4, p<0.001). Both EDOF CLs were rated significantly higher than MS for vision stability (p≤0.001), overall vision satisfaction (p≤0.003), haloes at night (p<0.001) and comfort (p≤0.008). EDOF1 CLs were rated significantly higher than PCMF for vision stability (p=0.002), overall vision satisfaction (p<0.001) and comfort (p=0.019).A significantly higher proportion of participants (p=0.012) were willing to purchase EDOF CLs (50-73%) compared to PCMF (40%) or MS (33%).
Despite providing better distance visual acuities with PCMF and MS, the EDOF CLs were subjectively preferred overall
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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