July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Short-term changes in choroidal thickness and axial length in children fitted with orthokeratology lenses of different compression factors
Author Affiliations & Notes
  • Jason Ki-kit Lau
    School of Optometry, The Hong Kong Polytechnic University, Hung Hom, Hong Kong
  • Sin-Wan Cheung
    School of Optometry, The Hong Kong Polytechnic University, Hung Hom, Hong Kong
  • Michael J Collins
    School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia
  • Pauline Cho
    School of Optometry, The Hong Kong Polytechnic University, Hung Hom, Hong Kong
  • Footnotes
    Commercial Relationships   Jason Lau, None; Sin-Wan Cheung, None; Michael Collins, None; Pauline Cho, None
  • Footnotes
    Support  Collaborative Research Agreement between PolyU and Menicon Co. Ltd., Japan (ZG3Z) and Research Residency Scheme of the School of Optometry, PolyU
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 1786. doi:
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    • Get Citation

      Jason Ki-kit Lau, Sin-Wan Cheung, Michael J Collins, Pauline Cho; Short-term changes in choroidal thickness and axial length in children fitted with orthokeratology lenses of different compression factors. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1786.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the influence of compression factor (CF) upon short-term changes in choroidal thickness (ChT) and axial length (AL) in young myopic children treated with orthokeratology (OK) and to examine the relationship between the magnitude of change in AL and ChT.

Methods : This was a within-subject, contralateral, double-masked clinical trial. OK lenses with different CFs (0.75 and 1.75 D) were fitted to the contralateral eyes of each subject in a randomized manner. AL (Lenstar) and ChT (Spectralis OCT) measurements were obtained prior to commencing OK lens wear and then weekly for one month. OCT images were segmented using customized software to determine the subfoveal ChT (with manual correction where appropriate). A repeated measures ANOVA was used to examine AL and ChT changes over time and between fellow eyes. Pearson correlation test was used to examine the correlation between the change in ChT and AL.

Results : Twenty-five children (mean age: 9.3 ± 1.0 years) with low myopia (-2.12 ± 1.00 D) and minimal astigmatism (-0.37 ± 0.37 D) and anisometropia (0.04 ± 0.61 D) completed the study. Baseline refraction (-2.30 ± 1.05 D), ChT (253.3 ± 56.4 µm) and AL (24.30 ± 0.64 mm) were well-matched between the fellow eyes.
There was no significant effect of CF upon ChT or AL (both p > 0.05). However, ChT and AL significantly changed over time (p < 0.005) in a quadratic trend of approximate anti-phase relationship (p < 0.001). ChT initially increased by 11.5 ± 12.1 µm at week 1 (p = 0.001) and gradually returned to its original thickness at week 4 while AL significantly decreased by 26.8 ± 6.9 µm at week 1 (p = 0.008) and returned to its original thickness at week 4. For both CFs, changes in ChT were only significantly correlated to changes in AL at week 3 (-0.56 < r < -0.41, p < 0.05).

Conclusions : Increasing the CF of OK lenses did not result in different changes in ChT and AL and the shortening of AL observed in OK treated children could not be entirely explained by an increase in ChT.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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