July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Minimum Ultrasonic Gain as an Objective Density Measurement for Vitreous Hemorrhages
Author Affiliations & Notes
  • Manuel A. Arturo Trujillo-Alvarez
    Asociación para Evitar la Ceguera en México, Mexico, DF, Mexico
  • Guillermo Salcedo-Villanueva
    Retina, Asociación para Evitar la Ceguera en México, Ciudad de México, Mexico
  • Mariana Mayorquín-Ruiz
    Ecography, Asociación para Evitar la Ceguera en México, Mexico, Mexico
  • Catalina Becerra-Revollo
    Ecography, Asociación para Evitar la Ceguera en México, Mexico, Mexico
  • Footnotes
    Commercial Relationships   Manuel A. Trujillo-Alvarez, None; Guillermo Salcedo-Villanueva, None; Mariana Mayorquín-Ruiz, None; Catalina Becerra-Revollo, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 1843. doi:
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      Manuel A. Arturo Trujillo-Alvarez, Guillermo Salcedo-Villanueva, Mariana Mayorquín-Ruiz, Catalina Becerra-Revollo; Minimum Ultrasonic Gain as an Objective Density Measurement for Vitreous Hemorrhages. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1843.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : The purpose of this research is to evaluate a novel measurement termed Minimum Ultrasonic Gain (MUG) in terms of its reproducibility as an objective mean to determine any vitreous humor opacity, such as vitreous hemorrhage (VH) and inflammatory or infectious vitritis

Methods : Patient’s charts with a diagnosis of VH, obtaining data from 50 eyes of 50 patients that had undergone an ocular ultrasound scan in one specific system. Demographic data, such as gender, age, diagnosis, best corrected visual acuity assessments (at the time of the hemorrhage) were converted from Snellen charts to its logarithmic minimum angle of resolution equivalent (logMAR) for statistical analysis and clinical VH grade were recorded into spreadsheets. All scans and MUG measurements were performed by two experienced ocular ultrasound ophthalmologists.
A 10 mega Hz, B-scan ultrasound probe was used to obtain a longitudinal image where the optic nerve head, macula, peripheral retina and external rectus muscle could be visualized
To obtain the MUG: The longitudinal image previously described is observed without any additional zoom, and with the highest amount of gain (in decibels [dB]) (110 dB). The scan’s gain is then lowered in order to obtain a completely echo-silent vitreous cavity. The point where there is no observable vitreous humor/VH is termed MUG, and the dBs are registered
To determine the reproducibility and objectivity of the MUG, intra-observer and inter-observer variability were evaluated. For every eye/image analyzed, 3 measurements of the MUG were obtained per grader. MUG results were blinded from the grader, and graders were masked to each other’s results. Only an unmasked researcher viewed, recorded, and analyzed the results
Demographic data is reported using descriptive statistics. For variability analysis of MUG, intraclass correlation coefficient (ICC) was performed. Normality in the distribution of the data was analyzed with the Shapiro-Wilk test

Results : Intra-Class grader 1: Cronbach`s Alpha 0.995, ICC single measures .984, ICC average measures .995
Intra-Class grader 2: Cronbach`s Alpha .998, ICC single measures .994, ICC average measures .998
Inter-Class grader 1 vs 2: Cronbach`s Alpha .966, ICC single measures .935, ICC average measures .966

Conclusions : MUG is a reproducible techniche intra/interobserver that could be use as a prognostic tool in the management of VH and other inflamatory diseases like endoftalmitis

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.


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