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MONTSERRAT PINTO CROKER, Daniela Meizner, Juan M Jimenez-Sierra; Vitreoretinal Interface Characteristics by Optical Coherence Tomography (OCT) in Patients with Adult-Onset Foveomacular Vitelliform Dystrophy (AOFVD).. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1844.
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© ARVO (1962-2015); The Authors (2016-present)
AOFVD is an uncommon disease with some characteristics yet to determine. This study describes the vitreo-retinal interface and Central Macular Thickness (CMT) in AOFVD.
This is a Retrospective, observational and comparative study.A consecutive series of 18 eyes of 9 patients clinically diagnosed with AOFVD at APEC Hospital Dr. Luis Sanchez Bulnes I.A.P were included in the study. A total of 18 eyes from 9 patients diagnosed with AOFVD were included from January 1st 2002 until December 31st 2016.Minimal criteria for defining AOFVD diagnosis included one or more round, elevated, yellowish macular lesion, with or without a hyperpigmented central spot and cuticular drusen.A t-student was employed to compare continuous variables, whereas, for non-normal distributed variables we used Mann-Whitney test. A Spearman correlation (r) was obtained between age and posterior vitreous detachment for all patients. A P < 0.05 was considered statistically significant. A D’Agostino-Pearson normality test was utilized for all variables. We used the SPSS v.20 software for statistical analysis and the GraphPad Prism v.6 for analysis and graphs.
In our study the main final BCVA was 0.449 LogMAR ±0.231 These results are in concordance with previously reported data by Quereques G., et al, who described initial and final BCVA of 0.32 ± 0.22 (range 0.1 - 1) and 0.39 ±0.28 (range 0.1 – 1.3) respectively. Additionally, our patients were able to read at least using one eye. The main factor contributing to poor visual outcome was macular atrophy shown by OCT and FA in two cases.We found no statistically significant differences regarding central macular thickness; nonetheless, these measurements were more heterogeneous for late stages of the disease, showing wide data dispersion (CTM values from 211 microns to 408 microns).In our study, we found that vitreo-macular adhesion was more frequent in older patients, describing a positive correlation coefficient between age and PVD. Based on these findings we believe that increased adhesion of the vitreous to the macula is present in AOFVD.
Even though measurements show no significant difference from those obtained at the first and last visit the results show vitreo-macular adhesion more frequent in older than younger patients.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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