July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Profound effect of age-related macular degeneration on visual acuity and the white matter projecting to locations of retinal damage
Author Affiliations & Notes
  • Shumpei Ogawa
    Ophthalmology, The Jikei university school of medicine, Tokyo, Minato-ku, Japan
    Ophthalmology, Atsugi city hospital, Kanagawa, Japan
  • Franco Pestilli
    Department of Computer Science, Indiana University, Bloomington, Indiana, United States
    Department of Intelligent Systems Engineering, Indiana university, Bloomington, Indiana, United States
  • Shoyo Yoshimine
    Research Institute for Time Studies, Yamaguchi university, Yamaguchi, Japan
  • Hiroshi Horiguchi
    Ophthalmology, The Jikei university school of medicine, Tokyo, Minato-ku, Japan
  • Masahiko Terao
    Research Institute for Time Studies, Yamaguchi university, Yamaguchi, Japan
  • Terumi Makino
    Ophthalmology, The Jikei university school of medicine, Tokyo, Minato-ku, Japan
    Ophthalmology, Atsugi city hospital, Kanagawa, Japan
  • Kenji Matsumoto
    Brain Science Institute, Tamagawa university, Tokyo, Japan
  • Tadashi Nakano
    Ophthalmology, The Jikei university school of medicine, Tokyo, Minato-ku, Japan
  • Yoichiro Masuda
    Ophthalmology, The Jikei university school of medicine, Tokyo, Minato-ku, Japan
  • Footnotes
    Commercial Relationships   Shumpei Ogawa, None; Franco Pestilli, None; Shoyo Yoshimine, None; Hiroshi Horiguchi, None; Masahiko Terao, None; Terumi Makino, None; Kenji Matsumoto, None; Tadashi Nakano, None; Yoichiro Masuda, None
  • Footnotes
    Support  JSPS Grant-in-Aid for Young Scientists (B) 17K18131
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 1852. doi:
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      Shumpei Ogawa, Franco Pestilli, Shoyo Yoshimine, Hiroshi Horiguchi, Masahiko Terao, Terumi Makino, Kenji Matsumoto, Tadashi Nakano, Yoichiro Masuda; Profound effect of age-related macular degeneration on visual acuity and the white matter projecting to locations of retinal damage. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1852.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : We investigated the impact of Age-related macular degeneration (AMD) on visual acuity and the visual white matter.

Methods : We combined optical coherence tomography (OCT), an adaptive cortical atlas and diffusion-weighted magnetic resonance imaging (dMRI) and tractography to separate optic radiation (OR) projections to different retinal eccentricities in human primary visual cortex. We exploited the known anatomical organization of the OR and clinically relevant data to segment the OR into three primary components projecting to fovea, mid- and far-periphery. We measured white matter tissue properties – (fractional anisotropy, linearity, planarity, sphericity) along the aforementioned three components of the optic radiation to compare AMD patients and controls.

Results : We found differences in white matter properties specific to OR white matter fascicles projecting to primary visual cortex locations corresponding to the location of retinal damage (fovea). Additionally, we show that the magnitude of white matter properties in AMD patients’ correlates with visual acuity. In sum, we demonstrate a specific relation between visual loss, anatomical location of retinal damage and white matter damage in AMD patients. Importantly, we demonstrate that these changes are so profound that can be detected using magnetic resonance imaging data with clinical resolution. The conserved mapping between retinal and white matter damage suggests that retinal neurodegeneration might be a primary cause of white matter degeneration in AMD patients.

Conclusions :
The results highlight the impact of eye disease on brain tissue, a process that may become an important target to monitor during the course of treatment.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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