July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Correlation of choroidal thickness changes with systemic risk factors and the severity of diabetic retinopathy (assessed by swept-source optical coherence tomography)
Author Affiliations & Notes
  • Hajnalka Horváth
    Ophtalmology, Semmelweis University, Budapest, Hungary
  • Illes Kovacs
    Ophtalmology, Semmelweis University, Budapest, Hungary
  • Gabor Laszlo Sandor
    Ophtalmology, Semmelweis University, Budapest, Hungary
  • Cecilia Czakó
    Ophtalmology, Semmelweis University, Budapest, Hungary
  • Zsuzsa Récsán
    Ophtalmology, Semmelweis University, Budapest, Hungary
  • Aniko Somogyi
    Internal Medicine, Semmelweis University, Budapest, Hungary
  • Zoltán Zsolt Nagy
    Ophtalmology, Semmelweis University, Budapest, Hungary
  • Mónika Ecsedy
    Ophtalmology, Semmelweis University, Budapest, Hungary
  • Footnotes
    Commercial Relationships   Hajnalka Horváth, None; Illes Kovacs, None; Gabor Laszlo Sandor, None; Cecilia Czakó, None; Zsuzsa Récsán, None; Aniko Somogyi, None; Zoltán Zsolt Nagy, None; Mónika Ecsedy, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 1933. doi:
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      Hajnalka Horváth, Illes Kovacs, Gabor Laszlo Sandor, Cecilia Czakó, Zsuzsa Récsán, Aniko Somogyi, Zoltán Zsolt Nagy, Mónika Ecsedy; Correlation of choroidal thickness changes with systemic risk factors and the severity of diabetic retinopathy (assessed by swept-source optical coherence tomography). Invest. Ophthalmol. Vis. Sci. 2018;59(9):1933.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate choroidal thickness (CT) in diabetic eyes, and to correlate it with the effect of systemic risk factors and the severity of diabetic retinopathy (DR).

Methods : Prospective cross-sectional study using swept-source optical coherence tomography. Choroidal thickness maps - according to the nine Early Treatment Diabetic Retinopathy Study subfields - of 96 treatment naiv eyes of 48 diabetic patients were compared to 46 eyes of 23 healthy controls. Choroidal thickness changes and their relation to diabetes, age, gender and hypertension (HT) was analysed. In diabetic patients, the effect of disease duration and blood hemoglobin A1C (HbA1C) level were also evaluated. Furthermore the association of CT and the severity of DR (no DR, nonproliferative DR, nonproliferative DR with diabetic macular edema and proliferative DR) was assessed.

Results : A significantly thinner choroid was measured in patients with diabetes compared to controls (p<0.005). In diabetic patients age (25 μm thinning per decade; p<0.001), male gender (p<0.001), the duration of the disease (15 μm decrease in CT / 10 duration years; p=0.02) and HT (p=0.003) were significant predictors of choroidal thinning in univariable regression models. The level of HbA1c proved not to be correlated with CT. After analysing the effect of systemic risk factors in multivariable model, the duration of diabetes remained a significant predictor of CT decrease (p = 0.03). There was a significant correlation between choroidal thinning and the different stages of DR (p = 0.002). In multivariable analysis, thinner CT was found to be a significant predictor of the presence of DR (p = 0.02), after adjusting for the effect of systemic risk factors.

Conclusions : Diabetes mellitus itself and DR progression affects CT significantly even after adjusting for the effect of confounding systemic risk factors. Duration of the disease seems to be a prominent predictor of choroidal thinning. Thinner CT proved to be correlated with the progression of DR.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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