July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Ocular and non-ocular precursor cells for corneal endothelial regeneration
Author Affiliations & Notes
  • Shigeto Shimmura
    Ophthalmology, Keio Univ School of Medicine, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Shigeto Shimmura, Cellusion Inc. (P)
  • Footnotes
    Support  Japan Agency for Medical Research and Development (AMED)
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2002. doi:https://doi.org/
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    • Get Citation

      Shigeto Shimmura; Ocular and non-ocular precursor cells for corneal endothelial regeneration. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2002. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Presentation Description : Current surgical treatment of corneal endothelial disease include keratoplasty procedures such as DMEK, DSAEK and PK. Regenerating the corneal endothelium with ocular or non-ocular stem cells is the next generation of available options for endothelial disease. While advances in stem cell biology and tissue engineering techniques have significantly advanced the field, there are still several issues that require attention including safety and regulatory matters before clinical application can be achieved. Steps required for stem cell therapy include a proof-of-concept approach using tissue specific stem/ progenitor cells, establishment of surgical techniques and deriving target cells from ocular and non-ocular precursor cells. This presentation will discuss various autologous and allogeneic sources of precursor cells for regenerating the corneal endothelium.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.


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